Evidence map›Paper›PMID 42620061›Full record

ArticleResearch square2026

Adenylosuccinate acts as a novel pro-angiogenic factor.

Brennon Schofield, Drew R Seeger, Derek Besch, Peddanna Kotha, Svetlana A Golovko, Bryon D Grove, Anahita Mansouripour, Meredith Parmer, Shahram Solaymani-Mohammadi, Mikhail Y Golovko

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brennon SchofieldDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Drew R SeegerDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Derek BeschDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Peddanna KothaDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Svetlana A GolovkoDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Bryon D GroveDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Anahita MansouripourDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Meredith ParmerDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Shahram Solaymani-MohammadiDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Mikhail Y GolovkoDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.

Funding

Tracking and Evaluation CoreU54GM128729 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI BASSON, MARC D. · 2018 to 2022
$20.3M
Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
Validation of Adenylosuccinate as a Novel Endogenous Pro-Angiogenic Factor in the BrainR01NS119279 · NINDS · UNIVERSITY OF NORTH DAKOTA · PI GOLOVKO, MIKHAIL Y · 2021 to 2025
$2.7M
NIGMS NIH HHS P20 GM113123NIGMS NIH HHS U54 GM128729NINDS NIH HHS R01 NS119279
6 · The paper itself

Abstract

We recently demonstrated a dramatic 77-fold increase in brain adenylosuccinate (AdSucc) concentration during ischemia, reaching ~0.56 mM levels. Previously, the role of AdSucc induction under decreased energy charge was attributed to the activation of purine nucleotide (PNC) and the tricarboxylic acid cycle (TCA). However, careful analysis of metabolomic alterations in the ischemic brain under decreased energy charge did not confirm this role. To begin addressing the additional biological significance of the increased AdSucc under low-energy conditions associated with ischemia, we tested its angiogenic properties. Using a mouse

Indexed as

AdenylosuccinateAngiogenesisBrainIschemiaStroke

Identifiers

PMID42620061
PMCPMC13484402

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.