ArticlemedRxiv : the preprint server for health sciences2026
Life course shaping of allostatic load across 17 countries: Evidence from England, the U.S., Europe, China and Indonesia.
Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Early life adversity is a recognised risk factor for poor health in later life, but its relationship with allostatic load (AL; a measure of cumulative physiological stress) remains underexplored across populations around the world. This study builds evidence to test a life course approach to AL using harmonised data from six longitudinal ageing cohorts: Health and Retirement Study (US, N=2,427), English Longitudinal Study of Ageing (England, N=2,038), The Irish Longitudinal Study on Ageing (Ireland, N=8,184), Survey of Health Ageing and Retirement in Europe (Europe, N=4,079), China Health and Retirement Longitudinal Study (China, N=5,220), and Indonesia Family Life Survey (Indonesia, N=1,243). Childhood information at aged ten to sixteen was collected retrospectively from adults aged 65 on average. An AL score is constructed using biomarker data and a latent construct of early life adversity constructed to address recall bias. Results show that early life poverty is significantly associated with raised AL in Ireland, China, and Indonesia, supporting the impact of early life experiences on older adulthood. However, studies from other countries do not confirm statistical significance. These findings document that experiencing poverty during development phase in some settings is associated with higher AL in later life, however further analyses are required to explore possible variations across different populations and their social and economic context. These results add further evidence that social determinants of health, including child poverty, in some settings, contribute to cumulative physiological stress across the life course, and that policies and actions to reduce child poverty can have beneficial effects not only as children, but also as older adults.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.