ArticlemedRxiv : the preprint server for health sciences2026
Surveying the Genomic Landscape of Mantle Cell Lymphoma Indicates the Importance of Multimodal Genomic and Transcriptomic Exploration.
Charlz Nithin Jerold, Brian Li, Matthew Mosior, David Russler-Germain, Anshu Dahal, Zachary Skidmore, Kelsy C Cotto, Malachi Griffith, Todd A Fehniger, Obi L Griffith and 2 more
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Charlz Nithin JeroldWashington University School of Medicine, Department of Medicine, St. Louis, MO 63108.ORCID 0009-0008-8568-7193 Brian LiWashington University School of Medicine, Department of Medicine, St. Louis, MO 63108.
Matthew MosiorWashington University School of Medicine, Department of Medicine, St. Louis, MO 63108.
David Russler-GermainWashington University School of Medicine, Department of Medicine, St. Louis, MO 63108.
Anshu DahalWashington University School of Medicine, Department of Medicine, St. Louis, MO 63108.
Zachary SkidmoreWashington University School of Medicine, Department of Medicine, St. Louis, MO 63108.
Malachi GriffithWashington University School of Medicine, Department of Medicine, St. Louis, MO 63108.
Todd A FehnigerWashington University School of Medicine, Department of Medicine, St. Louis, MO 63108.
Obi L GriffithWashington University School of Medicine, Department of Medicine, St. Louis, MO 63108.ORCID 0000-0002-0843-4271 Brad KahlWashington University School of Medicine, Department of Medicine, St. Louis, MO 63108.
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Paul Calabresi K12 Career Development Award for Clinical OncologyK12CA167540 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio, Ramaswamy Govindan · 2012 to 2026
$11.7MInformatics tools for identification, prioritization and clinical application of neoantigensU01CA248235 · NCI · WASHINGTON UNIVERSITY · PI GRIFFITH, MALACHI · 2020 to 2022
$1.3MDeep Sequencing of Relapse and Refractory Hodgkin Lymphoma Genomes: A Study of Tumor Biology and EvolutionK22CA266743 · NCI · WASHINGTON UNIVERSITY · PI GOMEZ, FELICIA · 2023 to 2025
$583kINTEGRATED ANALYSIS & INTERPRETATION OF WHOLE GENOME, EXOME & TRANSCRIPTOME SEQUENCE DATA IN CANCERK99HG007940 · NHGRI · WASHINGTON UNIVERSITY · PI GRIFFITH, MALACHI · 2015 to 2016
$264kNCATS NIH HHS UL1 TR002345NCI NIH HHS K12 CA167540NCI NIH HHS K22 CA266743NCI NIH HHS P30 CA091842NCI NIH HHS U01 CA248235NHGRI NIH HHS K99 HG007940
6 · The paper itselfAbstract
Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma characterized by heterogeneous clinical courses despite a common pathobiological initiating event. In this work we explore the genomic variants that characterize MCL and integrate transcriptomic data to comprehensively describe MCL biology. We performed whole exome sequencing (WES) on 28 tumor-normal pairs (lymph node and skin, respectively), as well as whole genome sequencing (WGS) and RNA sequencing on subsets of samples. We used established DNA and RNA analysis pipelines to detect single-nucleotide variants (SNV) and indels, structural variants, copy-number alterations, and RNA fusions. The canonical t(11;14)(q13;q32)
Indexed as
exomeMantle cell lymphomaRNA-seqwhole genome sequencing
Identifiers
PMID42619836
PMCPMC13484329
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