In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
26 authors.
Ryan J ShepherdDivision of Psychology and Mental Health, Faculty of Biology, Medicine and Health, The University of Manchester, UK.ORCID 0009-0008-1592-9732 Matthias PierceDivision of Psychology and Mental Health, Faculty of Biology, Medicine and Health, The University of Manchester, UK.ORCID 0000-0003-2182-0369 Nils MuhlertDivision of Psychology, Communication and Human Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, UK.ORCID 0000-0002-6414-5589 Mica KomarnyckyjDivision of Psychology and Mental Health, Faculty of Biology, Medicine and Health, The University of Manchester, UK.ORCID 0000-0002-6749-3685 Meg SheppardDivision of Psychology, Communication and Human Neuroscience, Faculty of Biology, Medicine and Health, The University of Manchester, UK.ORCID 0009-0007-5009-1739 Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm.ORCID 0000-0003-4595-1144 Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom.ORCID 0000-0002-5214-7421 Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland.ORCID 0000-0003-0114-4914 Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.ORCID 0000-0003-4809-5398 Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.ORCID 0000-0002-4900-4817 Andreas HeinzDepartment of Psychiatry and Psychotherapy, University of Tübingen, Germany; German Center for Mental Health (DZPG), Site Tübingen, Germany.ORCID 0000-0001-5405-9065 Frauke NeesInstitute of Medical Psychology, Ludwig-Maximilians-Universität (LMU) in Munich, Munich, Germany.ORCID 0000-0002-7796-8234 Dimitri Papadopoulos OrfanosUniversité Paris-Saclay, CEA, CNRS, BAOBAB, 91191, Gif-sur-Yvette, France.
Luise PoustkaDepartment of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.ORCID 0000-0002-7738-4394 Michael N SmolkaDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0001-5398-5569 Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm.ORCID 0000-0002-6225-9267 Nilakshi VaidyaCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Germany.ORCID 0000-0002-4600-7158 Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0002-9403-6121 Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland.ORCID 0000-0002-2790-7281 Paul WirschingDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID 0000-0003-1228-6846 Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Germany.ORCID 0000-0002-7740-6469 IMAGEN Consortium
Rebecca ElliottDivision of Psychology and Mental Health, Faculty of Biology, Medicine and Health, The University of Manchester, UK.ORCID 0000-0002-7602-010X Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MA decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9MENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683kNIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238Wellcome Trust
6 · The paper itselfAbstract
Introduction: Anhedonia is a transdiagnostic psychiatric symptom linked to increased functional connectivity between the prefrontal cortex and striatum. Here, we examined how dimensions of early adversity contribute to this profile of connectivity. Methods: In a European community sample of young adults (IMAGEN), we examined cross-sectional (n=613) and longitudinal (n=332) associations of adversity dimensions with resting-state fMRI-derived connectivity. We selected 10 ROIs from anhedonia literature, defined in the functional images as 4mm-radius spheres. We then used network-based regression models to identify clusters of ROI-ROI connections associated with threat and deprivation scores, using interaction terms to examine sex and age-specific associations. We also examined associations between adversity and anhedonia, operationalized using factor analysis of six items from self-report surveys. Results: At age 18-22, we identified sex-specific associations between deprivation and connectivity for a cluster of 9 ROI-ROI connections ( Conclusion: Compared to females, young adult males may be more vulnerable to developing anhedonia after experiencing deprivation in childhood. Dimensions of early adversity are linked to distinct pathways of frontostriatal development.
Indexed as
anhedoniabrain developmentearly adversityprefrontal cortexresting-state fMRIsex differences
Identifiers
PMID42619809
PMCPMC13483791
What OpenQuestion holds
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LicenceCC BY
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