Evidence map›Paper›PMID 42619718›Full record

ArticlebioRxiv : the preprint server for biology2026

Neuropixels 1536 Channel Quad Base probe reveals brain-wide communication underlying flexible sensorimotor sequences.

Yi-Ting Chang, Rajan Dasgupta, Mingyuan Dong, Jennifer Colonell, Bill Karsh, Alexandra Cheng, Ruben Hermans, Hasan Mahmud-Ul, Carolina Mora Lopez, Jan Putzeys and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yi-Ting ChangThe Solomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
Rajan DasguptaThe Solomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
Mingyuan DongThe Solomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
Jennifer ColonellHHMI Janelia Research Campus, Ashburn, VA, USA.
Bill KarshHHMI Janelia Research Campus, Ashburn, VA, USA.
Alexandra ChengDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD. USA.
Ruben Hermansimec, Leuven, Belgium.
Hasan Mahmud-Ulimec, Leuven, Belgium.
Carolina Mora Lopezimec, Leuven, Belgium.
Jan Putzeysimec, Leuven, Belgium.
Marleen Welkenhuysenimec, Leuven, Belgium.
Barundeb Duttaimec, Leuven, Belgium.
Austin R GravesThe Solomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.
Daniel O'ConnorThe Solomon H. Snyder Department of Neuroscience, Krieger Mind/Brain Institute, Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-9193-6714
Timothy HarrisHHMI Janelia Research Campus, Ashburn, VA, USA.

Funding

Top-down and bottom-up signals for flexible orofacial behaviorsU19NS137920 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI David Kleinfeld · 2024 to 2026
$15.9M
Neuropixels NXT: Integrated Silicon Probes for Large Scale Extracellular Recording in Rodents and PrimatesU01NS115587 · NINDS · JOHNS HOPKINS UNIVERSITY · PI HARRIS, TIMOTHY D · 2020 to 2024
$13.1M
NINDS NIH HHS U01 NS115587NINDS NIH HHS U19 NS137920
6 · The paper itself

Abstract

The brain orchestrates billions of neurons spanning hundreds of regions to drive behavior. High-density electrophysiology has provided insights into this process, but monitoring brain-wide patterns of spiking activity demands new tools. Here we present Neuropixels 2.0 Quad Base, a 1536-channel probe with four times the simultaneous recording capacity of state-of-art Neuropixels 2.0. Using two Quad Base probes, we performed 3072-channel recordings in mice trained to produce complex sequences of goal-directed licks. We decoded behavioral kinematics from neural populations across more than 20 brain regions and identified the spatiotemporal emergence of motor decision signals. The probes' high channel count further revealed expanded inter-neuronal functional subnetworks and latent dynamics across multiple areas-features significantly undersampled when channels were subsampled to mimic standard Neuropixels 2.0. Neuropixels 2.0 Quad Base offers a powerful tool to explore neural encoding of cognition and behavior at grand scale.

Identifiers

PMID42619718
PMCPMC13483804

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.