Evidence map›Paper›PMID 42619610›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2026

MLL1 Regulates T-Cell Phenotype via Notch Signaling During Abdominal Aortic Aneurysm Development.

Xiaobing He, Nicholas Juriga, Brennan Callow, Sama Salih, Amrita Joshi, Rachael Bogle, Lam C Tsoi, Andrea T Obi, Johann E Gudjonsson, Katherine A Gallagher and 1 more

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In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaobing He *Section of Vascular Surgery, Department of Surgery (X.H., N.J., B.C., S.S., A.J., A.T.O., K.A.G., F.M.D.), University of Michigan, Ann Arbor.ORCID 0009-0004-9907-7995
Nicholas Juriga *Section of Vascular Surgery, Department of Surgery (X.H., N.J., B.C., S.S., A.J., A.T.O., K.A.G., F.M.D.), University of Michigan, Ann Arbor.ORCID 0009-0005-8904-1275
Brennan CallowSection of Vascular Surgery, Department of Surgery (X.H., N.J., B.C., S.S., A.J., A.T.O., K.A.G., F.M.D.), University of Michigan, Ann Arbor.ORCID 0009-0001-0576-3934
Sama SalihSection of Vascular Surgery, Department of Surgery (X.H., N.J., B.C., S.S., A.J., A.T.O., K.A.G., F.M.D.), University of Michigan, Ann Arbor.
Amrita JoshiSection of Vascular Surgery, Department of Surgery (X.H., N.J., B.C., S.S., A.J., A.T.O., K.A.G., F.M.D.), University of Michigan, Ann Arbor.ORCID 0000-0001-6936-7132
Rachael BogleDepartment of Dermatology (R.B., L.C.T., J.E.G.), University of Michigan, Ann Arbor.ORCID 0000-0003-3544-3023
Lam C TsoiDepartment of Dermatology (R.B., L.C.T., J.E.G.), University of Michigan, Ann Arbor.ORCID 0000-0003-1627-5722
Andrea T ObiSection of Vascular Surgery, Department of Surgery (X.H., N.J., B.C., S.S., A.J., A.T.O., K.A.G., F.M.D.), University of Michigan, Ann Arbor.ORCID 0000-0001-7613-2366
Johann E GudjonssonDepartment of Dermatology (R.B., L.C.T., J.E.G.), University of Michigan, Ann Arbor.ORCID 0000-0002-0080-0812
Katherine A GallagherSection of Vascular Surgery, Department of Surgery (X.H., N.J., B.C., S.S., A.J., A.T.O., K.A.G., F.M.D.), University of Michigan, Ann Arbor.ORCID 0000-0002-8791-6980
Frank M DavisSection of Vascular Surgery, Department of Surgery (X.H., N.J., B.C., S.S., A.J., A.T.O., K.A.G., F.M.D.), University of Michigan, Ann Arbor.ORCID 0000-0002-5847-8993

Funding

BLRD VA IK2 BX006562
6 · The paper itself

Abstract

backgroundAbdominal aortic aneurysms (AAA) are characterized by progressive pathological vascular remodeling and a dysregulated immune microenvironment marked by an imbalance between anti-inflammatory regulatory T cells and proinflammatory T helper 17 (Th17) cells within the aortic wall. The molecular mechanisms governing CD4

methodsSingle-cell RNA-sequencing was performed on human AAA and nonaneurysmal aortic tissues. Two murine AAA models were utilized: AngII (angiotensin II) infusion with adeno-associated virus-mediated PCSK9 (proprotein convertase subtilisin/kexin type 9) gain-of-function expression and topical porcine pancreatic elastase application in C57BL/6J mice. Mice with CD4

resultsSingle-cell sequencing of human AAA tissue demonstrated marked upregulation of MLL1 and Notch1 signaling in CD4

conclusionsMLL1 epigenetically regulates Notch1 signaling to drive pathogenic Th17 polarization during AAA development. Targeting the MLL1 axis may represent a novel therapeutic strategy to limit aneurysmal progression.

Indexed as

Aorta, AbdominalAortic Aneurysm, AbdominalHistone-Lysine N-MethyltransferaseMyeloid-Lymphoid Leukemia ProteinReceptor, Notch1Th17 CellsAnimalsDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLPhenotypeSignal TransductionHistone-Lysine N-MethyltransferaseKMT2A protein, humanKmt2a protein, mouseMyeloid-Lymphoid Leukemia ProteinNOTCH1 protein, humanNotch1 protein, mouseReceptor, Notch1aortic aneurysms, abdominalinflammationphenotypeT-lymphocytesvascular remodeling

Identifiers

PMID42619610
PMCPMC13496003

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.