Evidence map›Paper›PMID 42619606›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2026

Adipose Tissue Immunosuppressive T Cells Regulate Atherosclerosis Development and Liver Fat Accumulation in Obesity.

Alecia M Blaszczak, Dharti Shantaram, Xilal Y Rima, Valerie P Wright, Joey Liu, Alan J Smith, Anahita Jalilvand, Anastasiia Amari, Chase D Bender, Dana Middendorf and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alecia M BlaszczakDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.ORCID 0000-0003-0052-4472
Dharti ShantaramDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.
Xilal Y RimaDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.ORCID 0000-0001-5633-5887
Valerie P WrightDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.ORCID 0000-0001-7647-3291
Joey LiuDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.
Alan J SmithDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.
Anahita JalilvandDivision of Trauma, Critical Care and Burn, Department of Surgery (A.J.), Wexner Medical Center, The Ohio State University, Columbus.ORCID 0000-0002-4954-1938
Anastasiia AmariDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.ORCID 0009-0002-3369-1998
Chase D BenderDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.ORCID 0009-0005-1652-4655
Dana MiddendorfDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.ORCID 0009-0002-6273-1135
Regina GebhardtDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.
Martha M YearsleyDepartment of Pathology (M.M.Y.), Wexner Medical Center, The Ohio State University, Columbus.ORCID 0000-0003-0352-1277
Debasish RoyCenter for Neuroscience, Indian Institute of Science, Bangalore (D.R.).ORCID 0000-0001-7516-8615
Edward A FisherDivision of Cardiology, Department of Medicine, NYU Langone Health Cardiovascular Research Center, New York University Grossman School of Medicine (E.A.F.).ORCID 0000-0001-9802-143X
David BradleyDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Pennsylvania State Health Milton S. Hershey Medical Center, Hershey (D.B.).ORCID 0000-0002-5777-5195
Willa A HsuehDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Diabetes and Metabolism Research Center (A.M.B., D.S., X.Y.R., V.P.W., J.L., A.J.S., A.A., C.D.B., D.M., R.G., W.A.H.), Wexner Medical Center, The Ohio State University, Columbus.ORCID 0000-0002-7321-4398

Funding

The Ohio State University Center for Clinical and Translational ScienceKL2TR001068 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$2.7M
Impact of the Adipose Tissue Microenvironment on AtherosclerosisR01HL135622 · NHLBI · OHIO STATE UNIVERSITY · PI HSUEH, WILLA A · 2018 to 2021
$2.1M
Postdoctoral Training in Cardiometabolic ScienceT32HL149637 · NHLBI · OHIO STATE UNIVERSITY · PI HSUEH, WILLA A, SMITH, SAKIMA AHMAD · 2020 to 2024
$1.5M
The impact of obesity on neutrophil swarming in septic surgical patientsK08GM157658 · NIGMS · OHIO STATE UNIVERSITY · PI Anahita Jalilvand · 2024 to 2026
$572k
Mechanisms of Adipose Tissue Immunoregulatory T cell (Treg) Exhaustion in ObesityR56AI157202 · NIAID · OHIO STATE UNIVERSITY · PI BRADLEY, DAVID PAUL, HSUEH, WILLA A · 2021 to 2021
$438k
NCATS NIH HHS KL2 TR001068NHLBI NIH HHS R01 HL135622NHLBI NIH HHS T32 HL149637NIAID NIH HHS R56 AI157202NIGMS NIH HHS K08 GM157658
6 · The paper itself

Abstract

backgroundObesity is associated with a loss of anti-inflammatory regulatory T cells (Tregs) in adipose tissue (AT), resulting in systemic inflammation. The adipocyte is a central modulator of CD4+T-cell subpopulations via antigen presentation through the MHCII (major histocompatibility complex class II). However, the role of adipocyte-induced AT inflammation due to changes in AT Tregs in obesity-related complications, such as atherosclerosis and metabolic-dysfunction-associated fatty liver disease (MAFLD), remains unknown.

methodsLdlr (low-density lipoprotein receptor)

resultsLoss of MHCII signaling in adipocytes prevented the obesity-mediated loss of AT Tregs, resulting in decreased insulin resistance, atherosclerosis, and MAFLD. In contrast, depletion of AT Tregs via IL (interleukin)-33 receptor-targeted immunotherapy with ST2 (suppression of tumorigenicity 2) reversed these improvements in Western high-fat diet-fed, 1-year-old aMHCll

conclusionsThese results suggest that AT immunosuppressive T cells play a pivotal role in regulating both atherosclerosis development and liver fat accumulation in obesity.

Indexed as

adipocytesantigen presentationatherosclerosisinflammationobesity

Identifiers

PMID42619606
PMCPMC13641187

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.