ArticleSmall (Weinheim an der Bergstrasse, Germany)2026
A Triangulenum-Based Biosensor Platform for Mapping Kinase Activity in T Cells.
Carmen Salto-Giron, Angélica Martín-Priego, Francisco Fueyo-González, María Mar Quesada-Moreno, Federico Movilla, Antonio Reinoso, Laura Espinar-Barranco, Rafael Salto, Amparo Navarro, Miguel Fribourg and 2 more
Abstract read
In one paragraphArticle in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Carmen Salto-GironNanoscopy-UGR Laboratory. Departamento de Fisicoquímica, Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente, Facultad de Farmacia, Campus Cartuja, Universidad De Granada, Granada, Spain.ORCID https://orcid.org/0000-0001-5573-0631 Angélica Martín-PriegoNanoscopy-UGR Laboratory. Departamento de Fisicoquímica, Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente, Facultad de Farmacia, Campus Cartuja, Universidad De Granada, Granada, Spain.ORCID https://orcid.org/0009-0001-4805-2788 Francisco Fueyo-GonzálezDepartment of Pharmacological Sciences, Institute for Translational Medicine and Pharmacology, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Federico MovillaNanoscopy-UGR Laboratory. Departamento de Fisicoquímica, Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente, Facultad de Farmacia, Campus Cartuja, Universidad De Granada, Granada, Spain.ORCID https://orcid.org/0000-0003-0800-6282 Antonio ReinosoDepartamento De Bioquímica y Biología Molecular II, Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente, Facultad De Farmacia, Campus Cartuja, Universidad De Granada, Granada, Spain.ORCID https://orcid.org/0009-0009-9511-9306 Laura Espinar-BarrancoDepartment of Medicine, Translational Transplant Research Center, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0001-5371-8671 Rafael SaltoDepartamento De Bioquímica y Biología Molecular II, Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente, Facultad De Farmacia, Campus Cartuja, Universidad De Granada, Granada, Spain.ORCID https://orcid.org/0000-0002-7044-3611 Angel OrteNanoscopy-UGR Laboratory. Departamento de Fisicoquímica, Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente, Facultad de Farmacia, Campus Cartuja, Universidad De Granada, Granada, Spain.ORCID https://orcid.org/0000-0003-1905-4183 Juan A González-VeraNanoscopy-UGR Laboratory. Departamento de Fisicoquímica, Unidad de Excelencia de Química Aplicada a Biomedicina y Medioambiente, Facultad de Farmacia, Campus Cartuja, Universidad De Granada, Granada, Spain.ORCID https://orcid.org/0000-0002-8199-1330 Funding
Redox homeostasis to capture regulatory T cell heterogeneity in transplantR21AI183028 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRAVEDI, PAOLO, FRIBOURG, MIGUEL · 2024 to 2025
$458kAgencia Estatal de Investigacion 10.13039/501100011033 PID2020-114256RB-I00Agencia Estatal de Investigación 10.13039/501100011033/ERDF PID2023-148243OB-I00Consejería de Universidad, Investigación e Innovación/ERDF R1C_2025_032Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/ERDF A-FQM-386-UGR20Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/ERDF P21_00212NIAID NIH HHS R21 AI183028NIH HHS R21AI183028Universidad de Granada/CBUA
6 · The paper itselfAbstract
Monitoring protein kinases in their native environment is essential for understanding cellular signaling. This study introduces triangulenium-based peptide biosensors for detection of the activity of two key protein kinases involved in T cell immune response: Akt1 and Src. The substrate biosensors incorporate a long-lifetime fluorophore from the triangulenium dye family, which undergoes quenching by photoinduced electron transfer (PET) from different amino acid side groups. Upon kinase-mediated phosphorylation, the PET quenching is significantly suppressed, increasing both fluorescence intensity and fluorescence lifetime (τ
Indexed as
Biosensing TechniquesT-LymphocytesHeLa CellsHumansMicroscopy, FluorescencePhosphorylationProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-aktbioimagingbiosensorDFTFLIMKinaseT Celltriangulenium
Identifiers
PMID42619562
PMCPMC13676840
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