Evidence map›Paper›PMID 42619424›Full record

ArticleExperimental physiology2026

Is resting muscle sympathetic nerve activity related to peripheral or cerebrovascular haemodynamics at high altitude? A retrospective analysis.

Ty J A MacDonald, Jenna C McCrone, Christabel Osei-Boateng, Connor D Wideman, Samantha L Tsioros, Joshua C Tremblay, Alexander Patrician, Connor A Howe, Geoff B Coombs, Benjamin S Stacey and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ty J A MacDonaldIntegrative Cerebrovascular and Environmental Physiology SB Laboratory, Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, Ontario, Canada.ORCID https://orcid.org/0009-0004-9491-1020
Jenna C McCroneIntegrative Cerebrovascular and Environmental Physiology SB Laboratory, Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, Ontario, Canada.ORCID https://orcid.org/0009-0005-9047-1926
Christabel Osei-BoatengIntegrative Cerebrovascular and Environmental Physiology SB Laboratory, Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, Ontario, Canada.ORCID https://orcid.org/0009-0003-2297-6813
Connor D WidemanIntegrative Cerebrovascular and Environmental Physiology SB Laboratory, Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, Ontario, Canada.
Samantha L TsiorosIntegrative Cerebrovascular and Environmental Physiology SB Laboratory, Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, Ontario, Canada.ORCID https://orcid.org/0009-0004-2228-0637
Joshua C TremblayCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.ORCID https://orcid.org/0000-0002-1667-294X
Alexander PatricianCentre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia - Okanagan, Kelowna, British Columbia, Canada.ORCID https://orcid.org/0000-0002-2634-6195
Connor A HoweDepartment of Sport Science, University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0000-0002-1133-2444
Geoff B CoombsInstitute for Applied Human Physiology, Bangor University, Bangor, UK.ORCID https://orcid.org/0000-0003-2667-0013
Benjamin S StaceyNeurovascular Research Laboratory, University of South Wales, Cardiff, UK.ORCID https://orcid.org/0000-0003-1005-7038
Lydia L SimpsonBristol Medical School, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0002-0357-6561
Mike StembridgeCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.ORCID https://orcid.org/0000-0003-0818-6420
Craig D SteinbackFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0001-7190-7046
Jonathan P MooreBiological Science, Northern Arizona University, Flagstaff, Arizona, USA.ORCID https://orcid.org/0000-0002-4244-8220
Travis D GibbonsBiological Science, Northern Arizona University, Flagstaff, Arizona, USA.ORCID https://orcid.org/0000-0003-3893-9948
Ryan L HoilandDepartment of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada.ORCID https://orcid.org/0000-0002-5657-0059
Francisco VillafuerteLaboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID https://orcid.org/0000-0003-0731-8911
Gilbert MoralezInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas and University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-0654-2383
Philip N AinslieCentre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia - Okanagan, Kelowna, British Columbia, Canada.ORCID https://orcid.org/0000-0001-6560-222X
Michael M TymkoIntegrative Cerebrovascular and Environmental Physiology SB Laboratory, Department of Human Health and Nutritional Sciences, College of Biological Science, University of Guelph, Guelph, Ontario, Canada.ORCID https://orcid.org/0000-0001-9945-339X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-altitude hypoxia elicits several profound physiological responses, including substantial increases in muscle sympathetic nerve activity (MSNA); however, the association of this heightened MSNA with cardiovascular and cerebrovascular haemodynamics remains unclear in lowlanders and indigenous highlander populations. We hypothesized that at high altitude resting MSNA would be associated with resting cardiovascular and cerebrovascular haemodynamics in lowlanders (n = 26), and Sherpa (n = 8) and Andean (n = 23) indigenous highlanders. Data were retrospectively analysed from two separate high-altitude expeditions to Nepal (2016; 5050 m) and Peru (2018; 4300 m). We assessed resting MSNA via radial or peroneal microneurography, and measured

Indexed as

blood pressure regulationbrachial artery blood flowcerebral blood flowendothelial functionhigh altitudesympathetic nerve activity

Identifiers

PMID42619424
PMCPMC13490907

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.