Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
7 authors.
Natalia I DmitrievaThe Laboratory of Cardiovascular Regenerative Medicine, National Heart Lung and Blood Institute, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-8074-6950
Jonathan RabinowitzWellness Lab and Louis and Gabi Weisfeld School of Social Work, Bar-Ilan University, Ramat Gan, Israel.
Eric S LeiferOffice of Biostatistics Research, National Heart Lung and Blood Institute, Bethesda, Maryland, USA.
Delong LiuThe Laboratory of Cardiovascular Regenerative Medicine, National Heart Lung and Blood Institute, Bethesda, Maryland, USA.
Mona N BahouthDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Manfred BoehmThe Laboratory of Cardiovascular Regenerative Medicine, National Heart Lung and Blood Institute, Bethesda, Maryland, USA.
Rebecca F GottesmanStroke Branch, National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, Maryland, USA.
Funding
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
Vascular remodeling in patients with rare genetic disordersZIAHL006077 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI BOEHM, MANFRED · 2010 to 2025
$22.9M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00003 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2022 to 2025
$5.1M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2022 to 2025
$5.0M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00004 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI WINDHAM, BEVERLY GWEN · 2022 to 2025
$4.8M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - FIELD CENTER - TASK ORDER 01, TASK AREA A75N92022D00002 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ARGANI, PEDRAM · 2022 to 2025
$4.7M
Intramural NIH HHS ZIA HL006077Intramural NIH HHS ZIA NS009435National Heart, Lung, and Blood Institute Intramural Research Program ZIAHL006077National Institute of Neurological Disorders and Stroke Intramural Research Program 1ZIANS009435NextGenerationEU, Romania's National Recovery and Resilience Plan CF46/28.07.2023NextGenerationEU, Romania's National Recovery and Resilience Plan PNRR-III-C9-2023-I8NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIH HHS U01HL096812NIH HHS U01HL096814NIH HHS U01HL096899NIH HHS U01HL096902NIH HHS U01HL096917
6 · The paper itself
Abstract
introductionIdentifying modifiable, accessible dementia risk factors is critical for prevention. Worldwide surveys indicate that about half of adults do not meet recommended fluid intake and may be chronically underhydrated.
methodsWe examined associations between intracellular hydration markers and dementia risk in 13,535 participants from the Atherosclerosis Risk in Communities (ARIC) study and 395,802 individuals from Israel's Leumit Health Services. Serum sodium, glucose-corrected sodium, and tonicity were modeled using restricted cubic splines in adjusted Cox models of incident dementia.
resultsAcross both cohorts, with up to 30 years of follow-up, dementia risk showed a nonlinear association with hydration markers. Risk began increasing within the mid-normal range, around 141 mmol/L for serum sodium and 287 mosmol/kg for tonicity, reaching a 1.5- to 3-fold increase at the upper end and beyond. DISCUSSION: These findings suggest hypertonic underhydration as early marker of dementia risk and support adequate water intake and glycemic control for dementia prevention.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Serum sodium, tonicity, and risk of dementia in cohort and healthcare populations. · full record | OpenQuestion