Evidence map›Paper›PMID 42619316›Full record

ArticleMolecular plant pathology2026

The Fungal Pathogen Fusarium graminearum Can Hydrolyse Tryptamine-Derived Hydroxy-Cinnamic Acid Amide Defence Compounds, and Generates Highly Increased Auxin Levels in Wheat via Copper Amine-Oxidases.

Thomas Svoboda, Eduardo Beltran, Pia Spörhase, Philipp Fruhmann, Anika Bartholomäus, Gerlinde Wiesenberger, Ulrich Gueldener, Bernhard Seidl, Asja Ceranic, Rudolf Krska and 3 more

Abstract read
In one paragraph

Article in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Thomas SvobodaInstitute of Microbial Genetics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.ORCID https://orcid.org/0000-0003-0502-301X
Eduardo BeltranInstitute of Bioanalytics and Agro-Metabolomics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.
Pia SpörhaseInstitute of Microbial Genetics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.
Philipp FruhmannInstitute of Microbial Genetics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.ORCID https://orcid.org/0000-0001-9165-5202
Anika BartholomäusInstitute of Microbial Genetics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.
Gerlinde WiesenbergerInstitute of Microbial Genetics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.
Ulrich GueldenerInstitute of Genome Oriented Bioinformatics, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.ORCID https://orcid.org/0000-0001-5052-8610
Bernhard SeidlCore Facility Bioactive Molecules: Screening and Analysis, BOKU University, Tulln, Austria.
Asja CeranicInstitute of Bioanalytics and Agro-Metabolomics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.
Rudolf KrskaInstitute of Bioanalytics and Agro-Metabolomics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.
Rainer SchuhmacherInstitute of Bioanalytics and Agro-Metabolomics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.
Franz BerthillerInstitute of Bioanalytics and Agro-Metabolomics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.ORCID https://orcid.org/0000-0001-5883-2879
Gerhard AdamInstitute of Microbial Genetics, Department of Agricultural Sciences, BOKU University, Vienna, Austria.ORCID https://orcid.org/0000-0002-3008-3797

Funding

Amt der NÖ Landesregierung WST3-T-95/020-2013Austrian Science Fund DOI 10.55776/F37Deutsche Forschungsgemeinschaft LAP3714
6 · The paper itself

Abstract

The important cereal pathogen Fusarium graminearum is not only able to produce trichothecene toxins, like deoxynivalenol, but also the plant hormone auxin (indole-3-acetic acid, IAA). Highly elevated levels of IAA and auxin derivatives such as IAA-glucoside or IAA amino-acid conjugates were observed in the susceptible wheat cultivar Apogee infected with F. graminearum. We report here that the fungal pathogen can hydrolyse tryptamine-derived hydroxycinnamic acid amides produced in high amounts during plant defence and is able to convert the released tryptamine in high yield into IAA. We investigated the role of copper amine-oxidase candidate genes, which code for enzymes converting tryptamine into the IAA precursor indole-3-acetaldehyde. After consecutive knock-out of seven copper amine oxidases the resulting septuple-mutant strain (aoxΔ

Indexed as

AmidesCoumaric AcidsFusariumIndoleacetic AcidsTriticumTryptaminesHydrolysisPlant DiseasesAmidesCoumaric AcidsIndoleacetic AcidstryptamineTryptaminesFusarium head blighthydroxycinnamic acid amidesindole‐3‐acetic acidplant hormone

Identifiers

PMID42619316
PMCPMC13490858

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.