Evidence map›Paper›PMID 42619234›Full record

ArticleNMR in biomedicine2026

High-Resolution Imaging of Extracellular pH in Mouse Liver Tumor.

Jessica Gois Santana, Sara Kurdi, Lisa Marie Helene Peschke, Sandeep Kumar Mishra, Fahmeed Hyder, Julius Chapiro, Daniel Coman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica Gois SantanaDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0002-4370-5823
Sara KurdiDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0001-8235-4336
Lisa Marie Helene PeschkeDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0009-0009-8862-5016
Sandeep Kumar MishraDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0002-1016-0206
Fahmeed HyderDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0001-7822-4002
Julius ChapiroDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Daniel ComanDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.ORCID https://orcid.org/0000-0002-6289-0817

Funding

Interleaved 1H/23Na imaging for invasive and proliferative phenotypes of brain tumorsR01CA280871 · NCI · YALE UNIVERSITY · PI Dewan Syed Fahmeed Hyder · 2023 to 2026
$2.2M
Modulating the immuno-metabolic interplay in liver cancer with cryoablationR21CA274152 · NCI · YALE UNIVERSITY · PI COMAN, DANIEL · 2023 to 2024
$413k
National Institutes of Health (NIH) R01 CA280871National Institutes of Health (NIH) R21 CA274152NCI NIH HHS R01 CA280871NCI NIH HHS R21 CA274152
6 · The paper itself

Abstract

Extracellular acidosis is a biologically important feature of the tumor microenvironment in the liver, promoting immune evasion, angiogenesis, and resistance to therapy, and representing a mechanistically important and potentially targetable axis in liver cancer. Imaging extracellular pH (pH

Indexed as

Extracellular SpaceLiver NeoplasmsMagnetic Resonance ImagingAnimalsCell Line, TumorHydrogen-Ion ConcentrationMiceMice, Inbred C57BLReproducibility of Resultsacidosisimmuno‐metabolic interplayliver cancermagnetic resonance spectroscopic imagingmetabolic imagingtumor microenvironment

Identifiers

PMID42619234
PMCPMC13490760

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.