Evidence map›Paper›PMID 42619051›Full record

ReviewImmunology and cell biology2026

The Imbalance Between Tumor Immunosurveillance and Tumor Immune Escape in Glioblastoma.

Sarah J MacDonald, Matthew Drill, Padmakrishnan C Jayakrishnan, Richard P Sequeira, Terence J O'Brien, Rosalind L Jeffree, Mastura Monif

Abstract readReview
In one paragraph

Review in Immunology and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah J MacDonaldDepartment of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0009-0005-7773-7902
Matthew DrillDepartment of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-7946-1309
Padmakrishnan C JayakrishnanDepartment of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0009-0007-8982-3116
Richard P SequeiraDepartment of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-8434-7460
Terence J O'BrienDepartment of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
Rosalind L JeffreeDepartment of Neurosurgery, Alfred Health, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-7663-2694
Mastura MonifDepartment of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-6404-9768

Funding

Brain Foundation AustraliaNational Health and Medical Research Council 2011590
6 · The paper itself

Abstract

Cancer immunosurveillance is the immune-mediated identification and elimination of malignant cells and is an essential mechanism to inhibit cancer growth. However, during cancer progression, tumors evolve various strategies to evade effective immune-mediated eradication, a process termed tumor immune escape. Glioblastoma (GBM) is the most common form of primary brain cancer and illustrates the delicate balance between immune escape and effective immunosurveillance, and the subsequent consequences upon acquiring various strategies of evasion. GBM exhibits several strategies that drive tumor immune escape, including downregulating antigen presentation, inhibiting immune cell function, and fostering immunosuppression. This is further amplified by the tumor-promoting effects of other tumor microenvironment constituents, such as neurons and astrocytes, and the immune system's dual role in tumor suppression and tumor persistence. Collectively, this facilitates immunologically unchecked outgrowth, manifesting as a highly aggressive, treatment-resistant disease with a universally lethal outcome for patients with GBM.

Indexed as

Brain NeoplasmsGlioblastomaImmunologic SurveillanceTumor EscapeAnimalsHumansMonitoring, ImmunologicTumor Microenvironmentglioblastomaimmune escapeimmune evasion

Identifiers

PMID42619051
PMCPMC13628426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.