ArticleJournal of cardiothoracic surgery2026
The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure.
Article in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivePatients with chronic heart failure (CHF) have a high mortality rate. The aim of this research is to examine the clinical value and molecular mechanisms of the lncRNA T cell receptor gamma chain-associated AS1 (TRG-AS1) in CHF.
methodsThe TRG-AS1 expression in 116 CHF patients was assessed by qRT-PCR. The diagnostic and prognostic value of TRG-AS1 was evaluated through ROC and COX survival analysis. The correlation between TRG-AS1 and clinical parameters was examined using Pearson's correlation analysis. Cell growth and death were assessed using the CCK-8 assay and double-staining methods. ELISA was used to detect inflammatory factors. The DLR assay was used to verify the interaction between TRG-AS1, miR-139-5p, and RUNX1.
resultsTRG-AS1 is upregulated in CHF (P < 0.0001) and is positively correlated with BNP (r = 0.500, P < 0.0001) and CRP levels (r = 0.398, P < 0.0001), while negatively correlated with LVEF (r=-0.605, P < 0.0001). TRG-AS1 is an risk factor for poor patient prognosis (HR = 3.043, 95%CI: 1.359-6.816, P = 0.007) and possesses good diagnostic value (AUC = 0.895, 95%CI: 0.852-0.938, Sensitivity: 84.5%, Specificity: 80.0%, P < 0.0001). Knocking out TRG-AS1 enhances cell proliferation, reduces apoptosis, alleviates oxidative stress, and inhibits the release of inflammatory factors by reducing the binding to miR-139-5p (P < 0.01).
conclusionTRG-AS1 may serve as a new diagnostic biomarker for CHF. The TRG-AS1/miR-139-5p axis may represent a potential therapeutic target for CHF. Furthermore, RUNX1 has been preliminarily identified as a downstream target gene of this ceRNA.
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