ReviewNature structural & molecular biology2026
Ion transport as a determinant of membrane fusion and fission.
Review in Nature structural & molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
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Abstract
The balance between membrane fusion and fission dictates the size and shape of intracellular organelles: excess fusion causes their enlargement, and predominant fission leads to fragmentation and resorption. These processes are differentially affected by membrane tension. Fusion is favored by increased tension, and the opposite is true for fission. Variations in membrane tension therefore underlie organellar remodeling. In this Review, we analyze the central role of hydrostatic pressure generated by osmotic imbalance in dictating membrane traffic. Using the endocytic pathway as a framework, we describe the predominant role of ions and their transport pathways in establishing intraorganellar osmolarity. We illustrate the role of ion transport regulation in organellar volume homeostasis by analyzing the mechanism underlying the massive vacuolation that results from inhibition of phosphatidylinositol 3,5-bisphosphate synthesis by PIKfyve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.