Evidence map›Paper›PMID 42618795›Full record

ArticleNature2026

Human brain organoids record the passage of time over multiple years.

Irene Faravelli, Noelia Antón-Bolaños, Anqi Wei, Tyler Faits, Abhishek Sampath Kumar, Sophia Andreadis, Rahel Kastli, Marta Montero Crespo, Mara Steiger, Daniel Leible and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Irene Faravelli *Department of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.
Noelia Antón-Bolaños *Department of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6590-4316
Anqi WeiDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.
Tyler FaitsDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7524-6166
Abhishek Sampath KumarDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7918-6706
Sophia AndreadisDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.
Rahel KastliDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3810-6228
Marta Montero CrespoDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7895-5961
Mara SteigerDepartment of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID http://orcid.org/0000-0002-3747-685X
Daniel LeibleMcGovern Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0009-0006-5491-6673
Elizabeth ZhangMcGovern Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0009-0006-8032-9421
Bobae AnMcGovern Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Yaron MeirovitchDepartment of Molecular and Cellular Biology and The Center for Brain Science, Harvard University, Cambridge, MA, USA.
Sayara SilwalDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.
Sung Min YangDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA.
Alexander KovacsovicsDepartment of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Xian AdiconisStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Helene KretzmerDepartment of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID http://orcid.org/0000-0002-0723-4980
Joshua Z LevinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0170-3598
Edward S BoydenMcGovern Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0419-3351
Jeff LichtmanDepartment of Molecular and Cellular Biology and The Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0208-3212
Aviv RegevKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Alexander MeissnerDepartment of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.ORCID http://orcid.org/0000-0001-8646-7469
Paola ArlottaDepartment of Stem Cell & Regenerative Biology, Harvard University, Cambridge, MA, USA. paola_arlotta@harvard.edu.ORCID http://orcid.org/0000-0003-2184-2277

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human brain develops and matures over an exceptionally prolonged period of time that spans nearly two decades of life. Processes that govern species-specific aspects of human postnatal brain development are difficult to study in animal models

Indexed as

AgingBrainOrganoidsAnimalsDNA MethylationEpigenomicsFemaleHumansMaleNeural Stem CellsNeuronsTime Factors

Identifiers

PMID42618795
PMCPMC13581598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.