Evidence map›Paper›PMID 42618789›Full record

ArticleNature2026

Pervasive phosphorylation by phage T7 kinase disarms bacterial defences.

Tara Bartolec, Karin Mitosch, Clément Potel, Federico Corona, Alessio Ling Jie Yang, Nicolai Karcher, Mira Lea Burtscher, Alexandra Koumoutsi, Isabelle Becher, Lena Sarah Müller and 5 more

Abstract read
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In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tara Bartolec *Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5291-6972
Karin Mitosch *Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Clément Potel *Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Federico CoronaMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0743-5520
Alessio Ling Jie YangMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4981-872X
Nicolai KarcherMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-7894-8182
Mira Lea BurtscherMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2628-0795
Alexandra KoumoutsiGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8368-4193
Isabelle BecherMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Lena Sarah MüllerMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Jacob BobonisGenome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9293-9733
Manjeet KumarMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Marco GalardiniCluster of Excellence RESIST (EXC 2155), Hannover Medical School (MHH), Hannover, Germany.
Athanasios TypasMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. athanasios.typas@embl.de.ORCID http://orcid.org/0000-0002-0797-9018
Mikhail M SavitskiMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. mikhail.savitski@embl.de.ORCID http://orcid.org/0000-0003-2011-9247

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria and bacteriophages are in a constant arms race to develop defence and anti-defence systems, respectively. Currently known phage-encoded anti-defence systems are specific to the activity of the targeted bacterial defence system. Here we identify a mechanism by which the T7 bacteriophage broadly counteracts bacterial defences using protein phosphorylation. Its kinase (T7K), which has been reported to redirect the function of a few host proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.