Evidence map›Paper›PMID 42618785›Full record

ArticleNature2026

A biased allosteric modulator is a molecular glue for β

Jiemin Shen, Teja Nikhil Peddada, Konstantin E Komolov, Francesco De Pascali, Alexander M Garces, Haoqing Wang, Muhammad Ehsan, Pil Seok Chae, Michael T Lerch, Jeffrey L Benovic and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Jiemin Shen *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3977-0681
Teja Nikhil Peddada *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5132-2064
Konstantin E KomolovDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6799-4626
Francesco De PascaliDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Alexander M GarcesDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.
Haoqing WangDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Muhammad EhsanDepartment of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, South Korea.ORCID http://orcid.org/0000-0002-4723-7924
Pil Seok ChaeDepartment of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, South Korea.
Michael T LerchDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-8173-4879
Jeffrey L BenovicDepartment of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.
Jun XuDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. xuj8@sustech.edu.cn.ORCID http://orcid.org/0000-0002-1600-583X
Brian K KobilkaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu.ORCID http://orcid.org/0000-0001-5958-3990

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Family A G-protein-coupled receptors (GPCRs) are typically described as monomers, yet growing evidence suggests that they can form dimers with distinct signalling properties

Identifiers

PMID42618785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.