Evidence map›Paper›PMID 42618784›Full record

ArticleNature2026

Functional role of skull lymphoid structures in CNS immunosurveillance.

Jang Hyun Park, Daviti Abramishvili, Gustavo Gastão Davanzo, Ruben Silva, Xingxing Gu, Siling Du, Daniel D Lee, Bernd H Zinselmeyer, Jackson S Turner, Gwendalyn J Randolph and 2 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jang Hyun ParkBrain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA. janghyun@wustl.edu.ORCID http://orcid.org/0000-0003-0942-4873
Daviti AbramishviliBrain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.
Gustavo Gastão DavanzoBrain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-6723-1933
Ruben SilvaBrain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0009-0000-5074-2537
Xingxing GuBrain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.
Siling DuBrain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-1540-3585
Daniel D LeeDepartment of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.
Bernd H ZinselmeyerDepartment of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0003-4172-6767
Jackson S TurnerDepartment of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-4396-6265
Gwendalyn J RandolphDepartment of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-9045-1195
Igor SmirnovBrain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.
Jonathan KipnisBrain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.ORCID http://orcid.org/0000-0002-3714-517X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence demonstrates that the central nervous system (CNS) is not disconnected from the peripheral immune system; however, precisely how the adaptive immune system surveils the CNS remains a critical question. Recent findings reveal that channels between the skull and the dura mater facilitate the exchange of cerebrospinal fluid and immune cells between the CNS and skull bone marrow of mice under both homeostatic and disease conditions

Indexed as

Bone MarrowCentral Nervous SystemImmunologic SurveillanceLymphoid TissueSkullAdaptive ImmunityAnimalsB-LymphocytesCD40 LigandFemaleGerminal CenterImmunity, HumoralInterferon-gammaInterleukin-21InterleukinsLymphocyte ActivationCD40 LigandInterferon-gammaInterleukin-21Interleukins

Identifiers

PMID42618784
PMCPMC13626955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.