Evidence map›Paper›PMID 42618778›Full record

ArticleNature cardiovascular research2026

Alpha protein kinase 3 gene therapy restores heart function in mouse and human models of cardiomyopathy.

James W McNamara, Ellen B Keen, Rebecca Sutton, Yinghan She, Hannah Huckstep, Lina H H Le, Neda R Mehdiabadi, Madhavan S Venkatesh, Brendan Griffen, Richard J Mills and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

James W McNamaraMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia. james.mcnamara@mcri.edu.au.ORCID http://orcid.org/0000-0003-3754-6405
Ellen B KeenMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.
Rebecca SuttonMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.ORCID http://orcid.org/0009-0001-7959-001X
Yinghan SheMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.ORCID http://orcid.org/0009-0003-5123-0885
Hannah HuckstepMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-5451-294X
Lina H H LeMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.ORCID http://orcid.org/0009-0009-5368-8391
Neda R MehdiabadiMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-1929-2034
Madhavan S VenkateshGladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.
Brendan GriffenDynomics Inc, San Francisco, CA, USA.
Richard J MillsMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-9735-2595
Christina V TheodorisGladstone Institute of Cardiovascular Disease, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1658-1447
James E HudsonSchool of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Drew M TitmarshDynomics Inc, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8379-6136
Sean J HumphreyMurdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-2666-9744
Enzo R Porrello *Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia. enzo.porrello@mcri.edu.au.ORCID http://orcid.org/0000-0001-6105-7463
David A Elliott *Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia. david.elliott@mcri.edu.au.ORCID http://orcid.org/0000-0003-1052-7407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Truncating variants in the ALPK3 gene (encoding alpha protein kinase 3) cause severe cardiomyopathy for which no curative treatment exists

Indexed as

CardiomyopathiesCardiomyopathy, DilatedGenetic TherapyMyocardial ContractionMyocytes, CardiacProtein KinasesVentricular Function, LeftAnimalsConnectinDependovirusDisease Models, AnimalGene Therapy AgentsHumansMaleMiceMutationConnectinProtein KinasesProtein Serine-Threonine KinasesTNNI3K protein, humanTTN protein, human

Identifiers

PMID42618778
PMCPMC13561881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.