ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2026
Glucagon-like peptide-1 receptor agonists and retained gastric contents on endoscopy: a prospective observational study.
Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
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Abstract
purposeRetrospective evidence suggests that glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are associated with retained gastric contents (RGC) after standard 8-hr fasting, possibly increasing aspiration risk. The primary aim of this study was to compare the incidence of RGC on upper endoscopy after appropriate preoperative fasting in patients taking GLP-1 RAs vs patients not taking GLP-1 RAs.
methodsWe conducted prospective observational study of 256 patients scheduled for elective endoscopy involving stomach visualization. The primary outcome was RGC, defined as solid content or liquid-only content > 1.5 mL·kg
resultsThere was no statistically significant difference in the incidence of RGC between patients taking GLP-1 RAs (8%) vs controls (6%, P = 0.55). There were no occurrences of aspiration events, procedure abortion, or relevant conversion to general anesthesia. Endoscopy physician-reported concern of significant gastric contents was higher in the GLP-1 RA group compared with the control group (19% vs 7%).
conclusionsIn this small observational study, no statistically significant increase in RGC was noted when preprocedural instructions advised patients to hold GLP-1 RAs 1 week prior to endoscopy and follow a preprocedural 24-hr clear liquid diet.
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