ArticleInternational urology and nephrology2026
Ten-year oncological and renal outcomes after radical cystectomy with orthotopic neobladder reconstruction.
Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRadical cystectomy (RC) with orthotopic neobladder (ONB) reconstruction provides oncological control and quality-of-life benefits for selected patients with bladder cancer. However, prognostic factors for recurrence remain to be elucidated. Herein, we evaluated 10-year oncological and renal functional outcomes after ONB reconstruction at a single institution.
methodsWe retrospectively reviewed 84 patients who underwent RC with ONB reconstruction at our institution between June 2009 and August 2024. We analyzed clinicopathological characteristics, perioperative variables, and postoperative outcomes.
resultsAll patients were male, the median age was 68 (range, 45-82) years, and the median follow-up was 79 months (range, 4-179). The 5- and 10-year recurrence-free survival (RFS) rates were 76% and 72%, and the 5- and 10-year cancer-specific survival rates were 92% and 83%, respectively. In univariate analysis, postoperative nodal status, adjuvant chemotherapy, and postoperative T status were significantly associated with RFS. Multivariate analysis identified postoperative T status as the only independent predictor (HR 2.976, 95% CI 1.179-7.5132, p = 0.021). Renal function declined gradually from a mean eGFR of 65.3 ± 15.5 mL/min/1.73 m
conclusionsONB reconstruction after RC provided durable oncological control and acceptable long-term renal function over 10 years. Renal deterioration was primarily associated with postoperative hydronephrosis. These findings support the feasibility of ONB in appropriately selected patients with careful postoperative surveillance.
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