ArticleEvidence-based dentistry2026
The effect of vitamin D supplementation on periodontal health: a systematic review and meta-analysis.
Article in Evidence-based dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
objectivesThis systematic review aimed to assess whether supplementation with vitamin D compared to no supplementation or placebo might provide a significant benefit for periodontal and peri-implant health in terms of changes in probing pocket depth (PPD), clinical attachment level (CAL), tooth loss and implant loss.
methodsThree databases were searched to identify randomized controlled trials (RCTs) and controlled clinical trials (CCTs) looking at the effect of vitamin supplementation on periodontal and peri-implant health with a minimum follow-up of 1 month. Meta-analysis of the weighted mean differences (MD), with 95% confidence intervals (CI) was performed when ≥3 studies with the same characteristics and follow-up were identified.
resultsFourteen articles (13 RCTs and 1 CCT) were included for qualitative assessment, but none assessed the impact of vitamin D on peri-implant health. Three studies assessing the impact of vitamin D supplementation to non-surgical periodontal therapy with a total of four subset of subjects were included in the meta-analysis on changes in PPD with an estimated mean difference of 0.0023 mm (95% CI: -0.0378 mm to 0.0424 mm), which was not statistically significant (p = 0.9110). DISCUSSION: Vitamin D supplementation does not confer a statistically significant additional benefit to non-surgical periodontal therapy in reducing probing pocket depth. Although vitamin D may exert anti-inflammatory effects on gingival tissues, current evidence is limited, heterogeneous, and insufficient to support a clear clinical recommendation. No studies addressing peri-implant health outcomes were identified, underscoring a gap in the literature. Well-designed, long-term randomized controlled trials that control for confounding variables are needed to determine the role of vitamin D supplementation in periodontal health.
Identifiers
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Registered trials
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