ArticleHypertension research : official journal of the Japanese Society of Hypertension2026
Family history of hypertension may have a stronger association with the incidence of hypertension than previously estimated: the SBS study.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A family history (FH) of hypertension is associated with an increased risk of new-onset hypertension. However, the risk of FH estimated in normotensives using conventional methods may have been somewhat underestimated by excluding early-onset cases, who are highly likely to have FH of hypertension. This large-scale longitudinal study on a middle-aged population (mean age: 46.8 years) revealed that the hazard ratio of FH of hypertension for the development of hypertension was higher when calculated for the entire study population (N = 34,792), including hypertensives at baseline by treating them as left-censored cases, using an interval-censored Cox proportional hazards model (1.73, 95% confidence interval: 1.67-1.79, P < 0.001) than that calculated in normotensives (n = 28,271) using a conventional Cox model (1.35, 95% confidence interval: 1.28-1.44, P < 0.001). The effect of changes in the possible confounders during the follow-up period was negligible. Thus, the risk of FH of hypertension for the development of hypertension may be higher than previously reported.
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