ArticleNPJ biofilms and microbiomes2026
Global analysis of infant gut microbiota revealed distinctive maturation dynamics across lifestyles.
Article in NPJ biofilms and microbiomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The infant gut microbiome develops during the first years of life and influences long-term health through its interaction with immune system development. However, our understanding of early-life microbiome assembly is biased by the predominance of infants with industrialized lifestyles from North America and Europe. Here, we address this bias by assembling a globally representative dataset of 14,979 infant gut microbiomes from 2746 individuals to train a microbiome maturation model that can characterize lifestyle-specific patterns of microbial maturation as a function of age. Models trained exclusively on industrialized infants perform poorly when applied to non-industrialized datasets. In contrast, more diverse models, including individuals from both lifestyles, achieve increased correlation between microbial and chronological age (ΔR
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