ArticleNature communications2026
Injury-driven stromal exhaustion disrupts intrinsic regenerative capability.
Sixun Wu, Hirotaka Matsumoto, Keita Kondo, Aiko Kuroda, Jumpei Morita, Takeshi Moriishi, Shawn A Hallett, Yuki Matsuo, Azumi Noguchi, Mitsuaki Ono and 5 more
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Sixun WuDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Keita KondoDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Aiko KurodaDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Jumpei MoritaDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Takeshi MoriishiDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yuki MatsuoDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Azumi NoguchiDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Mitsuaki OnoDepartment of Oral Rehabilitation and Regenerative Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan.
Makoto AbeDepartment of Tissue and Developmental Biology, Graduate School of Dentistry, The University of Osaka, Osaka, Japan.
Yuki MatsushitaDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. yukimatsushita@nagasaki-u.ac.jp.ORCID http://orcid.org/0000-0001-9577-3249 Funding
Japan Agency for Medical Research and Development (AMED) JP256f0137009MEXT | Japan Science and Technology Agency (JST) JPMJFR2111MEXT | Japan Society for the Promotion of Science (JSPS) JP25H01073, JP24KK0168, JP21H03124, JP20KK0356
6 · The paper itselfAbstract
Bone marrow stromal cells, marked by leptin receptor (Lepr) and C-X-C motif chemokine ligand 12 (Cxcl12), orchestrate osteogenesis and maintain bone homeostasis. Following injury, these stromal cells directly generate reparative bone and subsequently restore the marrow microenvironment, a process widely regarded as a reliable regenerative response. However, it remains unclear whether stromal cells retain full regenerative capacity after prior injury. Here, we show that Lepr
Indexed as
Bone RegenerationMesenchymal Stem CellsAdipocytesAdipogenesisAnimalsbeta CateninCell DifferentiationChemokine CXCL12MiceMice, Inbred C57BLOsteogenesisReceptors, LeptinStromal CellsWnt Signaling Pathwaybeta CateninChemokine CXCL12Cxcl12 protein, mouseleptin receptor, mouseReceptors, Leptin
Identifiers
PMID42618571
PMCPMC13490406
What OpenQuestion holds
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