ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2026
Design, verification and validation of a spatially confined magnetic nanoparticle thermal therapy device for conformal thermal dose contouring.
Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundMagnetic nanoparticle thermal therapy (MNTT) can localize heat within tumors, but non-uniform nanoparticle distribution can limit thermal dose coverage. Spatially confined MNTT (SC-MNTT) addresses this limitation by using a static magnetic field (SMF) to suppress heating outside a selected field-free region (FFR). However, SC-MNTT platforms require improved FFR steering and closed-loop temperature control. PURPOSE: This study developed and validated a low-cost, four-permanent-magnet SC-MNTT platform for spatially selective heating, dynamic FFR steering, and controlled thermal dose delivery in phantom models.
methodsThe device combined four permanent magnets, an induction coil, motion and heating control, fiber-optic thermometry, and autotuning proportional-integral-derivative (PID) control. SMF maps and alternating magnetic field (AMF) defined operating conditions. Three-vial verification experiments evaluated spatially selective heating under pulsed AMF exposure. Liver-phantom validation experiments tested pulsed heating and autotuning PID control using prescribed temperature setpoint, a CEM43 target of 8 [min], and a healthy-tissue limit of 39.50 [°C].
resultsThe four-magnet configuration shifted the FFR between selected targets and concentrated heating at the intended nanoparticle location. In three-vial experiments, the selected vial reached normalized heating intensity near 1.00, while non-target vials remained lower between 0.09-0.26, corresponding to selective heating with reduced off-target activation. In liver-phantom experiments, autotuning PID control maintained a mean target temperatures 43.44 ± 0.01 [°C], achieved prescribed CEM43 at selected tumor probes, and kept the designated healthy-tissue probe below the safety threshold. Mean overshoot remained below 1.1 [%].
conclusionThe four-magnet SC-MNTT platform enabled repeatable in-plane FFR steering, spatially confined heating, and closed-loop thermal dose delivery in phantom models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.