Evidence map›Paper›PMID 42617941›Full record

Observational studyInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2026

Characterization of the clinical forms of chronic chikungunya: an observational cohort study in Rio de Janeiro.

Josephine Bourner, Alessandra Dantas do Nascimento, Wim Alexander Fleischmann, Jeni Stolow, Leonardo L S Bastos, Grazielle Viana Ramos, Patricia T Bozza, Thiago L Moreno Souza, Jan Felix Drexler, Jose Cerbino Neto and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Josephine BournerFundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil; Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Brazil. Electronic address: josephine.bourner@proton.me.
Alessandra Dantas do NascimentoFundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Wim Alexander FleischmannUniversity Hospitals Heidelberg, Heidelberg, Germany.
Jeni StolowTulane University, New Orleans, United States.
Leonardo L S BastosFundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil; Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Brazil; Pontifícia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil.
Grazielle Viana RamosInstituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Brazil.
Patricia T BozzaFundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Thiago L Moreno SouzaLaboratório de Imunofarmacologia, IOC, Fiocruz, Rio de Janeiro, Brazil; Program on Surveillance in Health, Igaçu University, Nova Iguaçu, Brazil; Center for Technological Development in Health (CDTS), Fiocruz, National Institute for Science and Technology on Innovation on Diseases of Neglected Populations (INCT/IDPN), Rio de Janeiro, Brazil.
Jan Felix DrexlerCharité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany; German Centre for Infection Research (DZIF), Berlin, Germany.
Jose Cerbino NetoFundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Fernando A BozzaFundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil; Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Brazil; Nova Medical School, Lisbon, Portugal. Electronic address: bozza.fernando@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to characterize the clinical presentation of acute and chronic chikungunya virus infection in Brazil and identify predictors of chronic chikungunya.

methodsWe conducted a prospective observational cohort study in the emergency department of Hospital Quinta D'Or, Rio de Janeiro, between March 2016 and May 2017. Adults with suspected chikungunya were tested by RT-PCR for chikungunya, dengue, and Zika viruses. Patients with laboratory-confirmed chikungunya were enrolled. Clinical and demographic data were collected at baseline. At 90 days (D90), participants completed telephone follow-up assessing persistent symptoms, pain, and quality of life. Chronic disease was defined as ongoing arthralgia or myalgia at D90.

resultsAmong 134 PCR-confirmed cases, 100 completed follow-up and 38% reported chronic manifestations. Female sex (adjusted odds ratio [OR] 2.56, 95% confidence interval [CI] 1.02-6.25) and increasing age (adjusted OR 1.04, 95% CI 1.01-1.07) were independently associated with chronic disease. Prostration and retro-orbital pain showed trends towards association. Chronic symptoms were associated with pain interference affecting mood, work, and sleep.

conclusionsOver one-third of adults with laboratory-confirmed chikungunya experienced persistent symptoms at D90, with substantial functional impact. Early identification of patients at risk may support targeted follow-up and integration of long-term care into arboviral disease management.

Indexed as

Chikungunya FeverAdolescentAdultAgedArthralgiaBrazilChikungunya virusChronic DiseaseCohort StudiesFemaleHumansMaleMiddle AgedMyalgiaProspective StudiesQuality of LifeChikungunyaLong-term complicationsQuality of lifeRisk factors

Identifiers

PMID42617941
PMCPMC13615952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.