Evidence map›Paper›PMID 42617740›Full record

ArticleThe Journal of biological chemistry2026

G protein-coupled receptor kinase 3 regulates CCR7 signaling, trafficking, and T cell responses to CCL19 and CCL21.

Anahi Sanchez, Cesar I Cardona, Brian Kaiser, Charles A Bill, Mary E Miller, Daniel W Bassuk, Brant M Wagener, Michael A Brissette, Dalilia Ibanez, Manuel Llano and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anahi SanchezDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
Cesar I CardonaDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
Brian KaiserDepartment of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, Kansas City, Kansas, USA.
Charles A BillDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
Mary E MillerDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
Daniel W BassukDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA; Department of Internal Medicine, Texas Health Hospital, Texas Health Physicians Group, Fort Worth, Texas, USA.
Brant M WagenerDepartment of Anesthesiology and Perioperative Medicine, University of Alabama Birmingham School of Medicine, Birmingham, Alabama, USA.
Michael A BrissetteDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
Dalilia IbanezDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
Manuel LlanoDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
Colin A BillDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
Charlotte M VinesDepartment of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA; Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, Kansas City, Kansas, USA. Electronic address: cvines@utep.edu.

Funding

UTEP Border Biomedical Research CenterU54MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI Michael J Kenney · 2019 to 2026
$35.1M
XRAY CRYSTALLOGRAPHY CORE (JANUARY 1 - JUNE 30, 2005)P20RR016443 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI STEPHENS, EDWARD BRICE · 2001 to 2010
$21.3M
RISE Scholars Program at UTEPR25GM069621 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI AGUILERA, RENATO J · 2004 to 2021
$11.2M
CCR7 Chemotaxis Regulates Memory T Cell LocalizationSC1GM111172 · NIGMS · UNIVERSITY OF TEXAS EL PASO · PI VINES, CHARLOTTE M · 2015 to 2023
$3.0M
NCRR NIH HHS P20 RR016443NIGMS NIH HHS R25 GM069621NIGMS NIH HHS SC1 GM111172NIMHD NIH HHS U54 MD007592
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) can bind multiple ligands leading to differential signaling events termed biased signaling. GPCR kinases (GRKs) can control the phosphorylation patterns of a GPCR to regulate biased signaling. Since the functions of GRKs are dependent on the local cellular environment, our study focused on investigating the roles of GRK3 in regulating biased and overlapping signaling events downstream of CCR7 activation by its ligands CCL19 and CCL21 in T cells, where CCR7 is expressed endogenously. We found stable CCR7 internalization, Gα

Indexed as

arrestinChemokineG protein-coupled receptormigrationtrafficking

Identifiers

PMID42617740
PMCPMC13590099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.