ArticleJournal of the Academy of Nutrition and Dietetics2026
Dietary Fat, Inflammation, Circulating Tumor Cells, and Circulating Tumor DNA in Colorectal Cancer Survivors: An Exploratory Cross-Sectional Study.
Article in Journal of the Academy of Nutrition and Dietetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInflammation contributes to cancer recurrence through signaling pathways responsible for cell growth and metastasis, impacting circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). A high-fat diet may contribute to inflammation directly or indirectly through changes in visceral adipose tissue (VAT), a body composition compartment associated with inflammation.
objectiveThis analysis examined the association between percent energy from fat and circulating markers of inflammation, CTCs, and ctDNA.
designThis study was an exploratory secondary analysis of cross-sectional data from the Exercise and Colorectal Cancer Treatment trial conducted from August 2019 to May 2023 at Pennington Biomedical Research Center. Estimated percent energy from fat was collected at baseline using the National Cancer Institute Fat Screener. VAT was assessed using dual-energy x-ray absorptiometry. PARTICIPANTS/
settingParticipants included 57 stage I-III colorectal cancer survivors.
main outcome measuresOutcomes included measurements of 11 inflammatory biomarkers, CTCs, and ctDNA. STATISTICAL ANALYSES PERFORMED: Associations between percent energy from fat and inflammatory and tumor biomarkers were quantified using the Spearman correlation coefficient (r). Spearman partial correlations were adjusted for age, sex, race, cancer stage, and moderate-to-vigorous physical activity. Fully adjusted models additionally adjusted for VAT.
resultsIn unadjusted analyses, percent energy from fat was associated with soluble interleukin (IL)-6 receptor (r = 0.32; 95% confidence interval [CI], 0.06-0.53), soluble tumor necrosis factor receptor 1 (r = 0.32; 95% CI, 0.06-0.53), soluble tumor necrosis factor receptor 2 (r = 0.34; 95% CI, 0.09-0.55), and soluble IL-2 receptor alpha (r = 0.29; 95% CI, 0.03-0.51). Soluble tumor necrosis factor receptor 2 remained associated with percent energy from fat in adjusted (r = 0.32; 95% CI, 0.06-0.55) and fully adjusted (r = 0.28; 95% CI, 0.02-0.51) models.
conclusionsThis exploratory analysis provides insight into the mechanisms by which diet may impact cancer recurrence to support encouraging a healthy dietary pattern.
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