Evidence map›Paper›PMID 42617317›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2026

Honokiol-mediated reversal of cisplatin-induced transcriptomic changes in outer hair cells.

Chail Koo, Robert Fuentes, Prerita Pandya, Satoe Takahashi, Devin Thomas, Yingjie Zhou, Kazuaki Homma, Jin Li, Claus-Peter Richter, Xiaodong Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chail KooDepartment of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Robert FuentesDepartment of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Prerita PandyaDepartment of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Satoe TakahashiDepartment of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Devin ThomasDepartment of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Yingjie ZhouDepartment of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA.
Kazuaki HommaDepartment of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Hugh Knowles Center for Clinical and Basic Science in Hearing and Its Disorders, Northwestern University, Evanston, IL, USA.
Jin LiDepartment of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
Claus-Peter RichterDepartment of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA; Hugh Knowles Center for Clinical and Basic Science in Hearing and Its Disorders, Northwestern University, Evanston, IL, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Xiaodong TanDepartment of Otolaryngology Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA; Hugh Knowles Center for Clinical and Basic Science in Hearing and Its Disorders, Northwestern University, Evanston, IL, USA. Electronic address: xiaodong.tan@northwestern.edu.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Hearing Protection in Cisplatin ChemotherapyR01DC019434 · NIDCD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Xiaodong Tan · 2022 to 2026
$2.0M
Nikon CSU W1 SoRa for the Center for Advanced Microscopy and Nikon Imaging Center at Northwestern UniversityS10OD032270 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARVANITIS, CONSTADINA · 2023 to 2023
$600k
NCI NIH HHS P30 CA060553NIDCD NIH HHS R01 DC019434NIH HHS S10 OD032270
6 · The paper itself

Abstract

Cisplatin-induced hearing loss (CIHL) affects half a million cancer patients annually, but treatment strategies are limited. We have previously shown that honokiol, an antioxidant and otoprotective compound, upregulates mitochondrial sirtuin 3 (SIRT3) and protects against CIHL. In the present study, we investigated the molecular requirements of this protection using a Sirt3 knockout (Sirt3

Indexed as

Biphenyl CompoundsCisplatinHair Cells, Auditory, OuterLignansTranscriptomeAllyl CompoundsAnimalsAntioxidantsMiceMice, Inbred C57BLMice, KnockoutMitochondriaPhenolsSirtuin 3Superoxide Dismutase 2Allyl CompoundsAntioxidantsBiphenyl CompoundsCisplatinhonokiolLignansPhenolsSirtuin 3Superoxide Dismutase 2CisplatinHearing LossMitochondriaOuter hair cellsOxidative stressTranscriptome

Identifiers

PMID42617317
PMCPMC13662932

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.