ArticleJournal of gastrointestinal and liver diseases : JGLD2026
Time Trends and Impact on Treatment Outcomes of Psychiatric Diagnoses in Patients with Eosinophilic Esophagitis.
Article in Journal of gastrointestinal and liver diseases : JGLD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
aimsWhile mental illness is common in eosinophilic esophagitis (EoE), it is unknown whether psychiatric diagnosis frequency has varied over time or impacts treatment outcomes. We aimed to determine time trends in psychiatric diagnoses in EoE and whether such diagnoses affect EoE treatment outcomes.
methodsIn this retrospective cohort study of newly diagnosed EoE patients, medical records were examined to determine psychiatric diagnoses and psychoactive medication use. For patients who also had treatment with either a topical corticosteroid (tCS) or diet elimination and had a follow-up endoscopy with biopsy, histologic, endoscopic, and symptom responses were assessed. We evaluated time-trends in psychiatric diagnoses over >2 decades and compared tCS and diet elimination treatment response between patients with and without psychiatric diagnoses.
resultsOf 1291 newly diagnosed patients with EoE, 29% had a concomitant psychiatric diagnosis (18% depression; 24% anxiety) and 25% were on psychiatric medications. Over the 2-decade study timeframe, there was a slight overall increase in psychiatric diagnoses. However, diagnoses spiked in 2020 to >50% during the coronavirus disease 2019 (COVID-19) pandemic. There was no worsening in response rates for those with psychiatric diagnoses for either tCS or diet elimination treatment.
conclusionsPsychiatric diagnoses demonstrate a slight increase in EoE over the past 2 decades, though rates spiked during the COVID-19 pandemic, substantiating the burden of depression and anxiety during this time. Interestingly, the presence of a psychiatric disorder did not impact treatment outcomes to either tCS or diet elimination, so either option is viable in EoE patients with these diagnoses.
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