ArticleG3 (Bethesda, Md.)2026
Conserved sex-biased DNA methylation patterns target key developmental genes and reproductive function in two Poeciliidae species.
Article in G3 (Bethesda, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Cause-Effect Model of Master Sex Determination Gene Acquisition and the Evolution of Sex Chromosomes.International journal of molecular sciences · 2025Review
- Comparison of methodological approaches to the study of young sex chromosomes: A case study in Poecilia.Journal of evolutionary biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Sexual dimorphism provides a powerful framework for studying how regulatory mechanisms generate phenotypic divergence from a shared genome. Many sex-specific traits arise from differences in gene expression, which can be mediated by epigenetic mechanisms such as DNA methylation. These mechanisms contribute to the organization of gene regulatory variation across tissues, genes, and chromosomes, with potential consequences for the emergence and maintenance of sexually dimorphic phenotypes. Using a comparative epigenomic approach we investigate sex-biased DNA methylation in gonad and muscle tissue across 2 closely related Poeciliidae species, Poecilia reticulata and Poecilia wingei. We address 3 questions: (i) how conserved are sex-biased DNA methylation patterns across species and tissues; (ii) are conserved sex-biased methylation patterns associated with genes involved in developmental and transcriptional regulation; and (iii) are sex-biased epigenetic patterns enriched on the sex chromosome? We identify extensive conservation of sex-biased differentially methylated regions in gonadal tissue, with strong cross-species concordance, whereas muscle shows little conservation of sex-specific differential methylation. Conserved male-hypomethylated regions are enriched near genes involved in developmental transcriptional regulation and gonadal differentiation. Methylation-expression coupling distinguishes sex-biased reproductive gene functions, with male-biased genes enriched for spermatogenesis and motility and female-biased genes enriched for sperm-egg interaction processes. Sex-biased DNA methylation is broadly distributed across the genome, with localized regulatory regions on the sex chromosome. Together, these results show that conserved sex-biased DNA methylation is highly tissue-specific and associated with reproductive regulatory function, supporting a model in which gonadal epigenetic architecture reflects conserved regulatory organization underlying sexual dimorphism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.