ArticleAnnals of Indian Academy of Neurology2026
Effect of Cannabinoids use on Symptoms of Restless Leg Syndrome among Adults: A Scoping Review.
Article in Annals of Indian Academy of Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
5 authors.
Funding
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Abstract
BACKGROUND AND
objectivesRestless leg syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs, often accompanied by unpleasant sensations such as tingling, crawling, or aching. Symptoms typically worsen during periods of rest or inactivity, particularly in the evening or at night. This scoping review aimed to synthesize the existing literature on the efficacy of cannabis and cannabinoids in alleviating symptoms associated with RLS.
methodsA comprehensive search of electronic databases-including PubMed, Embase, Scopus, Cochrane Library, Google Scholar, ClinicalKey, and ClinicalTrials.gov-was conducted from database inception to April 30, 2025. Various keywords related to cannabis, cannabinoids, and RLS were used to identify relevant clinical studies.
resultsA total of 5,370 records were identified, of which seven studies met the inclusion criteria for final review. The evidence suggests that cannabis or cannabidiol may improve or prevent RLS symptoms.
conclusionsCurrent evidence indicates that cannabis, in various forms, may alleviate or prevent symptoms of RLS through multiple mechanisms. However, the existing literature is limited to case reports, cross-sectional surveys, and post hoc analyses. In the absence of high-quality randomized controlled trials, the evidence is insufficient to support clinical recommendations at this time.
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