ArticleScience advances2026
Endometriosis-derived iPSCs reveal conserved stromal maturation and endocrine responsiveness.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Engineering the human endometrium at the intersection of development and reproduction.Nature biomedical engineering · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
Endometriosis is a chronic, hormone-dependent disease characterized by altered endometrial stromal function, but mechanistic and translational studies have been hindered by the lack of tractable human models. Here, we establish an induced pluripotent stem cell (iPSC)-based platform derived from patients with endometriosis to model endometrial stromal differentiation in a controlled human context. Using a defined differentiation protocol, endometriosis-derived iPSCs transition from pluripotency through mesenchymal commitment toward stromal-like states and acquire transcriptional hormone responsiveness. Transcriptomic analyses reveal coordinated repression of pluripotency and proliferative programs with induction of stromal lineage signatures. Comparison with independent transcriptomic datasets demonstrated that in vitro-derived stromal cells progressively acquired gene expression profiles resembling eutopic endometrial stromal programs in endometriosis. Conditioned media from iPSC-derived stromal cells also induced transcriptional reprogramming in THP-1 macrophage-like cells. Together, these findings establish a patient-derived platform for investigating stromal differentiation and stromal-immune interactions in endometriosis.
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Registered trials
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