Evidence map›Paper›PMID 42616789›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A cloaked glutamate decarboxylase sustains the GABA shunt in

H Minh Thai, Debbie M Hunt, Yugen Miyahara, Manisha Priya, Htin L Aung, Rémi Zallot, Luiz Pedro S de Carvalho

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

H Minh Thai *Department of Chemistry, The Herbert Wertheim University of Florida (UF) Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458.ORCID 0009-0001-8107-6706
Debbie M Hunt *Mycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Yugen MiyaharaDivision of Health Sciences, Department of Microbiology and Immunology, Faculty of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.
Manisha PriyaDepartment of Chemistry, The Herbert Wertheim University of Florida (UF) Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458.ORCID 0000-0002-4919-4534
Htin L AungDivision of Health Sciences, Department of Microbiology and Immunology, Faculty of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.ORCID 0000-0002-0465-6256
Rémi ZallotDepartment of Life Sciences, Manchester Metropolitan University, Manchester M1 5GD, United Kingdom.ORCID 0000-0002-7317-1578
Luiz Pedro S de CarvalhoDepartment of Chemistry, The Herbert Wertheim University of Florida (UF) Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458.ORCID 0000-0003-2875-4552

Funding

Academy of Medical Sciences (The Academy of Medical Sciences) SBF009\1016Francis Crick Institute (FCI) 10060Royal Society Te Apārangi (Royal Society of New Zealand) RDF-UOO2101Wellcome 104785/B/14/ZWellcome Trust
6 · The paper itself

Abstract

Despite the exponential growth in genome sequencing, the functional annotation of genes, particularly the discovery of novel enzymatic activities, remains a formidable challenge. This gap is exacerbated by annotation biases that propagate assumptions about enzyme function across homologous sequences. Here, we report the identification of an unannotated enzymatic activity within a presumed well-characterized enzyme family. The gene

Indexed as

Bacterial Proteinsgamma-Aminobutyric AcidGlutamate DecarboxylaseMycobacterium tuberculosisCarboxy-LyasesKineticsBacterial ProteinsCarboxy-Lyasesgamma-Aminobutyric AcidGlutamate Decarboxylaseamino acid decarboxylasesenzyme functionGABA shuntmetabolomicsMycobacterium tuberculosis

Identifiers

PMID42616789
PMCPMC13506015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.