ArticleProceedings of the National Academy of Sciences of the United States of America2026
Regulatory logic of neuronal differentiation in the
McKenzie Treese, Yen-Chung Chen, Abigail Tyree, Rose Coyne, Cathleen Lake, Ojong Besong Tabi, Raghuvanshi Rajesh, Yu-Chieh David Chen, Huzaifa Hassan, Hua Li and 2 more
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
McKenzie TreeseStowers Institute for Medical Research, Kansas City, MO 64110.
Yen-Chung ChenDepartment of Biology, New York University, New York, NY 10003.ORCID 0000-0002-8529-1251
Abigail TyreeStowers Institute for Medical Research, Kansas City, MO 64110.
Rose CoyneStowers Institute for Medical Research, Kansas City, MO 64110.
Cathleen LakeStowers Institute for Medical Research, Kansas City, MO 64110.
Ojong Besong TabiStowers Institute for Medical Research, Kansas City, MO 64110.
Raghuvanshi RajeshDepartment of Biology, New York University, New York, NY 10003.
Yu-Chieh David ChenDepartment of Biology, New York University, New York, NY 10003.
Huzaifa HassanStowers Institute for Medical Research, Kansas City, MO 64110.
Hua LiStowers Institute for Medical Research, Kansas City, MO 64110.
Claude DesplanDepartment of Biology, New York University, New York, NY 10003.ORCID 0000-0002-6914-1413
Mehmet Neset ÖzelStowers Institute for Medical Research, Kansas City, MO 64110.
Funding
Stochastic choices in the retina and optic lobesR01EY013010 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2025
$9.1M
Neurogenesis of the optic lobesR01EY017916 · NEI · NEW YORK UNIVERSITY · PI Claude Desplan · 2007 to 2026
$8.0M
Gene Regulatory Networks of Synaptic SpecificityR00NS125117 · NINDS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI Mehmet Neset Ozel · 2024 to 2026
$740k
A Comprehensive Cell-Type-Specific Developmental Genetic Toolkit for the Drosophila Visual SystemR21NS140885 · NINDS · NEW YORK UNIVERSITY · PI Claude Desplan, Mehmet Neset Ozel · 2025 to 2026
$460k
Gene Regulatory Networks of Synaptic SpecificityK99NS125117 · NINDS · NEW YORK UNIVERSITY · PI OZEL, MEHMET NESET · 2022 to 2023
$254k
Esther A. and Joseph Klingenstein Fund (EAJK Fund) Neuroscience FellowshipHHS | NIH | National Eye Institute (NEI) EY013010HHS | NIH | National Eye Institute (NEI) EY017916HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS125117HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS140885NEI NIH HHS R01 EY013010NEI NIH HHS R01 EY017916NINDS NIH HHS K99 NS125117NINDS NIH HHS R00 NS125117NINDS NIH HHS R21 NS140885
6 · The paper itself
Abstract
Combinations of terminal selector transcription factors (tsTFs) are thought to establish and maintain the unique identities of the numerous cell types found in nervous systems. However, it remains largely unclear how tsTF combinations are specified during development and how they then coordinate the type-specific differentiation programs of each neuron. To investigate these regulatory mechanisms, we performed simultaneous single-cell RNA and ATAC (assay for transposase-accessible chromatin) sequencing on the
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Regulatory logic of neuronal differentiation in the · full record | OpenQuestion