ReviewPLoS biology2026
Encrypted immunity mediated by peptides.
Review in PLoS biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computational and experimental advances have led to the discovery of a large and diverse repertoire of bioactive peptides encrypted within proteins from across the tree of life. Mounting evidence suggests that these peptides can contribute to host defense not only through direct antimicrobial activity, but also through immunomodulatory and potentially broader physiological functions. This Essay synthesizes this emerging field from a broader biological perspective and explains the conceptual logic of immunity mediated by encrypted peptides. It proposes that such 'encrypted immunity' represents a previously underappreciated layer of host defense and physiology, with potential implications for therapeutics, diagnostics, and fundamental biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.