Evidence map›Paper›PMID 42616659›Full record

ArticleJMIR aging2026

Demoralization and Mental Disorders in Community-Dwelling Older Adults: Cluster Analysis.

Alice Onofrio, Maria Ferrara, Ilaria Domenicano, Martino Belvederi Murri, Tommaso Toffanin, Maria Giulia Nanni, Alessandra Canuto, Kerstin Weber, Jana Volkert, Holger Schulz and 3 more

Abstract read
In one paragraph

Article in JMIR aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alice Onofrio *Department of Neurosciences and Rehabilitation, University of Ferrara, via fossato di Mortara 64/a, Ferrara, 44121, Italy, 39 0532455813, 39 0532212240.ORCID http://orcid.org/0009-0001-3260-0882
Maria Ferrara *Department of Neurosciences and Rehabilitation, University of Ferrara, via fossato di Mortara 64/a, Ferrara, 44121, Italy, 39 0532455813, 39 0532212240.ORCID http://orcid.org/0000-0003-2143-1101
Ilaria DomenicanoDepartment of Neurosciences and Rehabilitation, University of Ferrara, via fossato di Mortara 64/a, Ferrara, 44121, Italy, 39 0532455813, 39 0532212240.ORCID http://orcid.org/0000-0002-1362-6120
Martino Belvederi MurriDepartment of Neurosciences and Rehabilitation, University of Ferrara, via fossato di Mortara 64/a, Ferrara, 44121, Italy, 39 0532455813, 39 0532212240.ORCID http://orcid.org/0000-0002-7262-3528
Tommaso ToffaninDepartment of Neurosciences and Rehabilitation, University of Ferrara, via fossato di Mortara 64/a, Ferrara, 44121, Italy, 39 0532455813, 39 0532212240.ORCID http://orcid.org/0000-0002-5510-5761
Maria Giulia NanniDepartment of Neurosciences and Rehabilitation, University of Ferrara, via fossato di Mortara 64/a, Ferrara, 44121, Italy, 39 0532455813, 39 0532212240.ORCID http://orcid.org/0000-0002-1085-4339
Alessandra CanutoValais Hospital - Hospital Centre of French-speaking Valais (CHVR), Sion, Switzerland.ORCID http://orcid.org/0009-0009-3328-0719
Kerstin WeberDepartment of Psychiatry, University of Geneva, Geneva, Switzerland.ORCID http://orcid.org/0009-0005-9354-0026
Jana VolkertClinic for Psychosomatic Medicine and Psychotherapy, University of Ulm, Ulm, Germany.ORCID http://orcid.org/0000-0003-1555-2599
Holger SchulzDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-5375-0030
Martin HärterDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7443-9890
Sylke AndreasInstitute of Psychology, Alpen-Adria University Klagenfurt, Klagenfurt, Austria.ORCID http://orcid.org/0000-0002-1060-1411
Luigi GrassiDepartment of Neurosciences and Rehabilitation, University of Ferrara, via fossato di Mortara 64/a, Ferrara, 44121, Italy, 39 0532455813, 39 0532212240.ORCID http://orcid.org/0000-0002-1050-4494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Demoralization negatively affects the quality of life, especially in people with mental disorders. Objective: This study aims to assess demoralization in a cohort of community-dwelling older adults, to identify groups of individuals who share similar characteristics in terms of mental health conditions and the severity of demoralization domains, and to investigate the different characteristics across these groups. Methods: Participants were enrolled in 3 centers as part of the cross-sectional MentDis_ICF65+ study and were assessed using the Demoralization Scale and the Composite International Diagnostic Interview at baseline. A cluster analysis was conducted using the partitioning around medoids algorithm with Gower's distance to classify individuals based on demoralization severity and the diagnosis of mental health disorders, allocating individuals to a distinct number of patterns by examining their similarities across these variables. Results: Among the final sample of 1369 participants, 3 clusters were identified: the "low psychopathology" cluster, with very few mental health diagnoses; the "affective" cluster, characterized by affective disorders (100% of participants); and the "anxiety" cluster, characterized by anxiety disorders (100% of participants). Men were prevalent in the "low psychopathology" cluster (n=635, 59.1%; Conclusions: The identification of different clusters of demoralization and mental health disorders in community-dwelling older adults, as well as sex-based differences, highlights the need for tailored mental health interventions in this vulnerable population.

Indexed as

Independent LivingMental DisordersAgedAged, 80 and overCluster AnalysisClustering AlgorithmsCross-Sectional StudiesFemaleHumansMaleQuality of Lifeanxietyclusterdemoralizationdepressionolder

Identifiers

PMID42616659
PMCPMC13488920

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.