ArticleSTAR protocols2026
Protocol for leveraging local ancestry and cross-ancestry genetic architecture to improve polygenic prediction in admixed populations.
Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Polygenic prediction is often less accurate in admixed populations due to limited representation in training data. Here, we present a protocol for building a polygenic prediction model using admixed populations from the All of Us program. We describe steps for variant extraction, phasing, local ancestry inference, and construction of polygenic risk score. This protocol may also serve as a useful reference for researchers aiming to conduct large-scale analysis in the All of Us Research Workbench cost-effectively. For complete details on the use and execution of the protocol, please refer to Zhou et al.
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