ArticleStem cell reviews and reports2026
A distinct Frequency of Endometrial Stem/Progenitor Cells (EnSCs) in the Ectopic and Eutopic Endometrium of Women with Endometriosis.
Article in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Endometriosis is a chronic estrogen-dependent disorder characterised by the growth of endometrial-like tissues outside the uterus. Recent data suggest a potential role for endometrial stem/progenitor cells in the development of endometriosis. However, evidence on the frequency of various stem cell populations in ectopic lesions and their paired eutopic counterparts remains limited. Hence, this study assessed the frequencies of endometrial stem cells and their characteristics in eutopic and ectopic endometria of women with endometriosis, and also probed whether these attributes differ in women without endometriosis. We analysed the frequencies of endometrial stem cells and their functional properties, isolated from ectopic lesions and paired eutopic endometrium, in women with endometriosis (n = 72) and women without endometriosis (n = 24). Comparative analysis revealed that the eutopic endometrium had a significantly increased frequency of SUSD2+ eMSCs in women with endometriosis than in those without the disease. Immunophenotypic characterisation of SUSD2+ eMSCs using classical MSC markers (CD73, CD90, CD105, and HLA-ABC) revealed that they retained more than 80% positivity in the eutopic endometrium, whereas variable expression of these markers was observed among ectopic lesions. On functional characterisation, the wound healing assay revealed that eMSCs from deep infiltrating endometriosis have increased migratory capacity compared to control and paired eutopic endometrium. Moreover, a preponderance of eEPCs (N-cadherin+ SSEA-1+ and N-cadherin- SSEA-1+) was observed in the eutopic endometrium of endometriosis. In contrast, a significantly increased frequency of Side Population was observed in ectopic lesions compared to eutopic endometrium. Besides Side Population, ovarian endometrioma exhibited a significantly increased frequency of pericyte eMSCs co-expressing CD146 and CD140b. These findings clearly demonstrated a distinct frequency of endometrial stem/progenitor cells in endometriosis. Collectively, this study underscores the predominance of endometrial stem cells and highlights altered immunophenotypic characteristics and enhanced migration capabilities of ectopic eMSCs, possibly driven by unique cellular microenvironments.
Indexed as
Identifiers
42616347What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.