Evidence map›Paper›PMID 42616261›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026

Hyperammonaemic encephalopathy and subsequent arthritis due to Ureaplasma urealyticum in a haematopoietic cell transplant recipient: a case report and literature review.

Claudia Bartalucci, Chiara Russo, Anna Maria Raiola, Massimiliano Gambella, Riccardo Varaldo, Carmen Di Grazia, Giulia Bartalucci, Marica Laurino, Emanuele Angelucci, Matteo Bassetti and 1 more

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Claudia BartalucciDivision of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genova, Genova, Italy.
Chiara RussoDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Sciences (DiNOGMI), University of Genoa, Genoa, 16132, Italy.
Anna Maria RaiolaAzienda Ospedaliera Metropolitana, IRCCS Ospedale Policlinico San Martino, UOC Ematologia e Terapie Cellulari, Genova, Italy.
Massimiliano GambellaAzienda Ospedaliera Metropolitana, IRCCS Ospedale Policlinico San Martino, UOC Ematologia e Terapie Cellulari, Genova, Italy.
Riccardo VaraldoAzienda Ospedaliera Metropolitana, IRCCS Ospedale Policlinico San Martino, UOC Ematologia e Terapie Cellulari, Genova, Italy.
Carmen Di GraziaAzienda Ospedaliera Metropolitana, IRCCS Ospedale Policlinico San Martino, UOC Ematologia e Terapie Cellulari, Genova, Italy.
Giulia BartalucciAzienda Ospedaliera Metropolitana, IRCCS Ospedale Policlinico San Martino, UOC Ematologia e Terapie Cellulari, Genova, Italy.
Marica LaurinoAzienda Ospedaliera Metropolitana, IRCCS Ospedale Policlinico San Martino, UOC Ematologia e Terapie Cellulari, Genova, Italy.
Emanuele AngelucciAzienda Ospedaliera Metropolitana, IRCCS Ospedale Policlinico San Martino, UOC Ematologia e Terapie Cellulari, Genova, Italy.
Matteo BassettiDivision of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genova, Genova, Italy.
Malgorzata MikulskaDivision of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genova, Genova, Italy. m.mikulska@unige.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperammonaemic encephalopathy (HE) is a rare but life-threatening complication increasingly linked to disseminated Ureaplasma infection in severely immunocompromised patients. We report a 31-year-old hematopoietic cell transplant (HCT) recipient who developed HE caused by U. urealyticum on day + 11 post-HCT, diagnosed by molecular testing and successfully treated with doxycycline and supportive therapy. Two months later, she developed relapsing septic arthritis with U. urealyticum detected in synovial fluid. Our literature review identified 17 cases of patients with haematological malignancies or cellular therapies and Ureaplasma infection: nine presented with arthritis alone, seven with HE alone, and one developed both manifestations sequentially.

Indexed as

Hematopoietic stem cell transplantHyperammonaemic encephalopathyImmunocompromised patientsMollicutesUreaplasma species

Identifiers

PMID42616261

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.