ArticleMolecular biology reports2026
Mitogenic potential of endogenous GlcNAc-specific lectins from rat brain cell nuclear membranes.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLectins are carbohydrate-binding proteins that participate in diverse biological processes, including cell adhesion, immune modulation, cell proliferation. While plant-derived lectins are well characterized for their proliferative effects, these properties of animal-derived lectins, particularly from neural tissues, remain poorly understood. This study aimed to evaluate the proliferative potential of a GlcNAc-specific lectin isolated from the cell nuclear membrane of rat brain cortex cells using the MTT assay.
methodsGlcNAc-specific lectins were purified via affinity chromatography from the cell nuclear membrane protein fraction of rat brain tissue. Human peripheral blood lymphocytes were incubated with the isolated lectins, and metabolic activity was assessed using the MTT colorimetric assay. Absorbance was measured at 540 nm. Statistical analysis was performed using Student's t-test.
resultsHuman peripheral blood lymphocytes with GlcNAc-specific lectins exhibiting hemagglutination activity showed a statistically significant, approximately ten times increase in optical density compared to controls (p < 0.05), indicating elevated metabolic activity. Although MTT reduction reflects mitochondrial function rather than direct cell proliferation, this increase suggests a mitogen-like proliferative effect. Remarkably, the GlcNAc-specific lectin continued to induce proliferative activity even having no hemagglutination activity.
conclusionThese findings suggest that rat brain-derived GlcNAc-specific lectins, which are Ca
Indexed as
Identifiers
42616250What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.