ArticlePediatric surgery international2026
The diagnostic value of interleukin-6, procalcitonin, and C-reactive protein in the severity of acute appendicitis in children.
Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundOur aim was to explore the diagnostic potential of IL-6, PCT, and CRP for the severity of acute appendicitis (AA) in children.
methodsWe carried out a retrospective study on 412 children (≤ 18 years) with surgically - confirmed AA and 160 children with non-AA abdominal pain as controls (October 2024-September 2025). AA cases were divided into mild (simple/suppurative) and severe(gangrenous/perforated) types based on pathology. We compared the biomarkers (IL-6, PCT, CRP, WBC, N%) among groups and used ROC curves to evaluate their diagnostic performance.
resultsThere were no significant differences in all indicators between the mild and the control group (all P > 0.05); all indicators in the severe group were higher than those in the control group (all P < 0.001); IL-6, PCT, and CRP in the severe group were higher than those in the mild group (all P < 0.001). IL-6 showed the best sensitivity (83.6%) with ROC AUC 0.776. CRP showed the best specificity (80.4%) with ROC AUC (0.774). An IL - 6 level > 21.7 pg/ml could independently predict severe AA. Combining the three biomarkers didn't improve diagnostic accuracy.
conclusionIL-6, PCT, and CRP are useful for assessing AA severity in children, The diagnostic performance of IL-6 is comparable to that of CRP, but superior to PCT.
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