Evidence map›Paper›PMID 42616089›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Quantification of vitreous VEGF-A121 and VEGF-A165 using an isoform-specific ELISA in proliferative diabetic retinopathy.

Ryoh Funatsu, Munekazu Yamakuchi, Kazunori Takenouchi, Yoshinori Azuma, Taiji Sakamoto, Teruto Hashiguchi, Hiroto Terasaki

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Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ryoh Funatsu *Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima, Japan.
Munekazu Yamakuchi *Department of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, Japan.
Kazunori TakenouchiDepartment of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, Japan.
Yoshinori AzumaShino-Test Corporation, Sagamihara, Japan.
Taiji SakamotoDepartment of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima, Japan.
Teruto HashiguchiDepartment of Laboratory and Vascular Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, Japan. k1581347@kadai.jp.
Hiroto TerasakiDepartment of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima, Japan. teracchi@m2.kufm.kagoshima-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the utility of specific enzyme-linked immunosorbent assays (ELISAs) for identifying vascular endothelial growth factor (VEGF)-A isoforms in the context of ophthalmic diseases, using proliferative diabetic retinopathy (PDR) as a representative model.

methodsThis was a single-institute, retrospective cohort study of patients with epiretinal membrane (ERM), rhegmatogenous retinal detachment (RRD), or PDR who underwent pars plana vitrectomy at Kagoshima University Hospital between January 2016 and August 2023. We measured vitreous VEGF-A

resultsThe study included 48 patients (48 eyes): 12 with ERM, 26 with RRD, and 10 with PDR. The concentration of VEGF-A

conclusionThese findings demonstrate this isoform-specific ELISA enables the measurement of VEGF-A isoforms in the vitreous. Quantification of vitreous VEGF-A isoforms may provide as crucial biomarkers for PDR.

Identifiers

PMID42616089

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