Evidence map›Paper›PMID 42616017›Full record

ArticleeLife2026

Three metabolic pathways replenishing the one-carbon pool collectively support growth and virulence of

Sandra Freier, Sarah Frentzel, Moritz Müller, Susan Scheffler, Sabrina Wamp, Tim Engelgeh, Janina Döhling, Dunja Bruder, Sascha Kahlfuss, Sven Halbedel

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sandra FreierFG11 Division of Enteropathogenic Bacteria and <italic>Legionella</italic>, Robert Koch Institute, Wernigerode, Germany.ORCID https://orcid.org/0009-0008-6071-4941
Sarah FrentzelInfection Immunology Group, Institute for Medical Microbiology and Hospital Hygiene, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.ORCID https://orcid.org/0009-0005-2379-061X
Moritz MüllerFG11 Division of Enteropathogenic Bacteria and <italic>Legionella</italic>, Robert Koch Institute, Wernigerode, Germany.ORCID https://orcid.org/0009-0003-6266-4849
Susan SchefflerFG11 Division of Enteropathogenic Bacteria and <italic>Legionella</italic>, Robert Koch Institute, Wernigerode, Germany.ORCID https://orcid.org/0009-0002-0315-9247
Sabrina WampFG11 Division of Enteropathogenic Bacteria and <italic>Legionella</italic>, Robert Koch Institute, Wernigerode, Germany.ORCID https://orcid.org/0000-0002-0387-4171
Tim EngelgehFG11 Division of Enteropathogenic Bacteria and <italic>Legionella</italic>, Robert Koch Institute, Wernigerode, Germany.ORCID https://orcid.org/0000-0003-1609-2299
Janina DöhlingFG11 Division of Enteropathogenic Bacteria and <italic>Legionella</italic>, Robert Koch Institute, Wernigerode, Germany.
Dunja BruderInfection Immunology Group, Institute for Medical Microbiology and Hospital Hygiene, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.ORCID https://orcid.org/0000-0003-3066-189X
Sascha KahlfussInstitute of Clinical Immunology and Cell Therapeutics, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.ORCID https://orcid.org/0000-0001-8813-1061
Sven HalbedelFG11 Division of Enteropathogenic Bacteria and <italic>Legionella</italic>, Robert Koch Institute, Wernigerode, Germany.ORCID https://orcid.org/0000-0002-5575-8973

Funding

Deutsche Forschungsgemeinschaft HA6830/2-1Deutsche Forschungsgemeinschaft HA6830/5-1
6 · The paper itself

Abstract

The bacterium

Indexed as

CarbonListeria monocytogenesMetabolic Networks and PathwaysAmino Acid OxidoreductasesAnimalsBacterial ProteinsCarbon-Sulfur LyasesFormate-Tetrahydrofolate LigaseGene DeletionGlycineGlycine Dehydrogenase (Decarboxylating)HumansMultienzyme ComplexesTetrahydrofolatesTransferasesVirulenceAmino Acid OxidoreductasesBacterial ProteinsCarbonCarbon-Sulfur LyasesFormate-Tetrahydrofolate LigaseGlycineglycine cleavage systemGlycine Dehydrogenase (Decarboxylating)Multienzyme ComplexesTetrahydrofolatesTransferasesadenineglycine decarboxylaseinfectious diseaseListeria monocytogeneslmo1876lmo1877microbiologytetrahydrofolate

Identifiers

PMID42616017
PMCPMC13489624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.