Evidence map›Paper›PMID 42615868›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand.

Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A Skryl'nikova, Maxim A Gureev, Zhi-Min Zhang, Zhang Zhang and 5 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zehong LinState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Kang DuanState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Rui WanState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Tao JiangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Jinzhe WeiState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Miao SunState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Mariia A Skryl'nikovaDepartment of Chemistry and Technology of Organic Nitrogen Compounds, Saint-Petersburg State Institute of Technology, Saint Petersburg, Russia.ORCID https://orcid.org/0000-0001-5618-7917
Maxim A GureevLaboratory of bio- and chemoinformatics, HSE University, Saint-Petersburg, Russia.ORCID https://orcid.org/0000-0002-0385-922X
Zhi-Min ZhangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0002-5088-5869
Zhang ZhangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Ke DingState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0001-9016-812X
Nan MaState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Tongzheng LiuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0003-0859-3923
Yi TanState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0002-0619-1173
Zhengqiu LiState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.ORCID https://orcid.org/0000-0002-0433-2147

Funding

Guangdong Basic and Applied Basic Research Foundation 2023B1515040016Guangdong Basic and Applied Basic Research Foundation 2024A1515013266Guangdong Basic and Applied Basic Research Foundation 2025A1515012357Guangdong Basic and Applied Basic Research Foundation 2026B1515020070Natural Science Foundation of China 22577037Natural Science Foundation of China 22577038Natural Science Foundation of China 82473109Natural Science Foundation of China W2512060Russian Science Foundation 25-43-02073Science and Technology Program of Guangdong Province 2023A0505050149Science and Technology Program of Guangdong Province 2024A1515013002Science and Technology Program of Guangdong Province 2025A0505080018
6 · The paper itself

Abstract

Targeted protein degradation represents a promising therapeutic strategy, yet its broader application is often limited by the scarcity of usable E3 ligases. Glutathione peroxidase 4 (GPX4) is a key target for inducing ferroptosis, but achieving sustained and potent inhibition remains challenging with conventional enzymatic inhibitors. Herein, we report the first small-molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide-based degrader DK-5070 effectively drives potent GPX4 degradation, achieving a DC

Indexed as

azidecell biologychemistrygpx4in vivoligandprotein degradationtargeted therapytherapeutic strategyubiquitin ligase

Identifiers

PMID42615868
PMCPMC13488481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.