ArticleArquivos brasileiros de cardiologia2026
HALP Score as a Novel Marker Associated with Coronary Collateral Circulation in Patients with Chronic Total Occlusion.
Article in Arquivos brasileiros de cardiologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Beyond Lesion Complexity: Do We Need a New Score for Chronic Total Occlusions?Arquivos brasileiros de cardiologia · 2026Article
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Abstract
backgroundCoronary collateral circulation (CCC) is a key determinant of myocardial viability and prognosis in patients with chronic total occlusion (CTO). The hemoglobin, albumin, lymphocyte, and platelet (HALP) score reflects nutritional status, immune competence, and systemic inflammation.
objectivesTo investigate the association between HALP score and CCC in patients with CTO.
methodsThis retrospective, single-center study included 269 patients with chronic coronary syndrome and angiographically confirmed CTO. Patients were classified according to Rentrop grades and dichotomized into poor CCC (Rentrop 0-1; n=119) and good CCC (Rentrop 2-3; n=150). HALP score, inflammatory markers, atherogenic indices, and angiographic scores were compared between groups. Multivariate logistic regression and receiver operating characteristic (ROC) analyses were performed. A p-value <0.05 was considered statistically significant.
resultsHALP score increased significantly across Rentrop grades (p<0.001) and was higher in patients with good CCC than in those with poor CCC (75.52±13.91 vs. 35.10±11.29; p<0.001). In multivariable analysis, HALP score (OR:0.88, 95% CI: 0.83-0.93; p<0.001), Gensini score (OR:1.14; p=0.002), and Prognostic Nutritional Index (OR:0.73; p=0.003) were independent predictors of good CCC. ROC analysis showed high discriminative ability (AUC=0.958; 95% CI: 0.93-0.98), with a cut-off value of >49.08 (91.3% sensitivity, 90.8% specificity). Atherogenic lipid indices were not significantly associated with CCC.
conclusionsHALP score is an independent and readily available marker associated with CCC in CTO patients and may serve as a practical tool for risk stratification, highlighting the importance of inflammatory, nutritional, and immune pathways in collateral development.
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