ArticleSao Paulo medical journal = Revista paulista de medicina2026
Potentially inappropriate medication use among older outpatients-prevalence and contributing factors: a retrospective study.
Article in Sao Paulo medical journal = Revista paulista de medicina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAdverse outcomes associated with potentially inappropriate medication (PIM) use are prevalent among older adults.
objectivesThis study aimed to determine the frequency of PIM use older outpatients and assess its association with chronic comorbidities and geriatric syndromes using the screening tool of older persons' prescriptions (STOPP) and screening tool to alert to right treatment (START) version 3 criteria. DESIGN AND
settingThis retrospective study included patients aged 65 years or older who attended geriatric outpatient clinics between January and June 2024.
methodsPIM use was evaluated using the STOPP/START version 3 criteria. Polypharmacy was defined as the use of five or more medications.
resultsAmong the 107 patients (median age, 77 years; range, 65-91), 71% (n = 76) used PIM, with a median of two PIMs per patient (range, 0-6). PIM use was significantly more prevalent among patients with polypharmacy (odds ratio [OR] = 3.986; 95% CI: 1.493-10.639; p = 0.006). Analyses based on the STOPP criteria also revealed significant associations of PIM use with dementia (OR = 13.240; 95% CI: 1.504-116.529; p = 0.02), polypharmacy (OR = 4.352; 95% CI: 1.476-12.827; p = 0.008), and a history of falls (OR = 3.131; 95% CI: 1.017-9.634; p = 0.047).
conclusionPolypharmacy was significantly associated with greater odds of PIM use among older adults. Based on the STOPP version 3 criteria, dementia and a history of falls were also associated with increased PIM use in this population.
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