ArticleCritical care science2026
Transforming pediatric intensive care unit outcomes in pediatric hematology-oncology and hematopoietic stem cell transplantation through golden hour care in a low- and middle-income country: a 10-year analysis.
Article in Critical care science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the impact of a care improvement bundle focused on early intervention, communication, and multidisciplinary collaboration by comparing outcomes across two 5-year periods before and after its implementation.
methodsA single-center, retrospective study was conducted in the Onco-Critical Care pediatric intensive care unit of a tertiary cancer referral hospital in South India, comparing outcomes from two eras: the pre-bundle cohort (2014 - 2018) and the post-bundle cohort (2019 - 2023). The study included children aged 1 month to 18 years, excluding those with postoperative, palliative, and end-of-life conditions. The care improvement bundle, introduced in 2019, aimed to enhance communication between oncology/transplant teams and the pediatric intensive care unit, enabling timely recognition and intervention ("golden hour care") for at-risk patients on the wards. The pre-bundle cohort had 4,000 hospital admissions and 533 pediatric intensive care unit admissions; the post-bundle cohort had 5,007 hospital admissions and 760 pediatric intensive care unit admissions.
resultsFrom 2014 - 2018, 516 hematopoietic stem cell transplantations and 336 new oncology cases were managed; from 2019 - 2023, these increased to 579 hematopoietic stem cell transplantations and 784 new oncology patients. Despite increased pediatric intensive care unit admissions and a higher proportion of transplanted infants in the later cohort, pediatric intensive care unit mortality declined significantly from 21.8% to 11.4% (p < 0.0001). The use of costly interventions decreased, with invasive ventilation dropping from 30.9% to 18.0% (p < 0.0001) and renal replacement therapy from 14.8% to 4.3% (p = 0.0001), indicating both improved outcomes and reduced resource utilization.
conclusionThe implementation of a care improvement bundle to foster interdisciplinary collaborative communication and earlier recognition of critical illness enabled golden hour care on the floors, resulting in significant improvements in outcomes for pediatric oncology and hematopoietic stem cell transplantation patients. This care improvement bundle is feasible, easily scalable, and can be systemically incorporated across the centers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.